Submitted for Publication: June 1, 2013; final revision received February 5, 2014; accepted February 5, 2014.
Published Online: March 27, 2014. doi:10.1001/jamaophthalmol.2014.685.
Study concept and design: Yang, Michaels, Pennesi.
Acquisition of data: Greninger, Reznick, Karr, Wilson, Weleber.
Analysis and interpretation of data: Yang, Michaels, Courtney, Wen, Weleber, Pennesi.
Drafting of the manuscript: Yang, Pennesi.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Yang, Pennesi.
Obtained funding: Pennesi.
Administrative, technical, and material support: Michaels, Wen, Greninger, Weleber.
Study supervision: Weleber, Pennesi.
Conflict of Interest Disclosures: Dr Wen is a consultant to QLT, Inc. Dr Weleber is a consultant to Novartis, Pfizer, and Wellstat; is a member of the scientific advisory board for Applied Genetic Technologies Corp; and serves on the scientific advisory board for the Foundation Fighting Blindness (the relationship has been reviewed and managed by Oregon Health & Science University). No other disclosures were reported.
Funding/Support: This work was supported by grants CF-CL-0612-0583-OHSU (Dr Yang) and CD-CL-0808-0469-OHSU (Dr Pennesi) from the Foundation Fighting Blindness, grant 1K08 EY0231186-01 from the National Institutes of Health (Dr Pennesi), Research to Prevent Blindness (Dr Pennesi), Medical Research Foundation (Dr Pennesi), Collins Medical Trust (Dr Pennesi), unrestricted grant C-CL-0711-0534-OHSU01 from the Foundation Fighting Blindness (Casey Eye Institute), and an unrestricted grant from Research to Prevent Blindness (Casey Eye Institute).
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Scott Pickell, BS, Casey Eye Institute, Oregon Health & Science University, captured the handheld SD-OCT images, Rebecca Clark, MS, CGC, Casey Eye Institute, Oregon Health & Science University, coordinated the genetic testing, and Laura Erker, PhD, Casey Eye Institute, Oregon Health & Science University, provided support with the manuscript; no compensation was received from the funding sponsors.