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Ophthalmic Images |

A Presentation of Invasive Squamous Cell Carcinoma (White Cornea)

Amir A. Azari, MD; Mozhgan Rezaei Kanavi, MD; Ashley M. Lundin, MD; Matthew J. Thompson, MD; Heather D. Potter, MD; Daniel M. Albert, MD
JAMA Ophthalmol. 2014;132(6):668. doi:10.1001/jamaophthalmol.2013.5311.
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Figure 1.

A 77-year-old man presented with corneal neovascularization and haze unresponsive to topical and subconjunctival steroids. Histopathology reveals corneal and conjunctival tissues with atypia of the surface epithelium (cytokeratin AE/AE3 [A]). The corneal stroma is infiltrated with atypical squamoid cells staining positive with cytokeratin AE/AE3 (B and C). All scale bars indicate 100 μm.

Figure 2.

Over the next 7 months, the corneal haze persisted (A), and vision worsened, with clinical suspicion for angle involvement. Patient underwent enucleation (B). Histopathology reveals an edematous cornea infiltrated with epithelioid cells with severe atypia staining with cytokeratin AE1/AE3 (C [scale bar, 700 μm], D [scale bar, 200 μm], and E [scale bar, 100 μm]).

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Figure 1.

A 77-year-old man presented with corneal neovascularization and haze unresponsive to topical and subconjunctival steroids. Histopathology reveals corneal and conjunctival tissues with atypia of the surface epithelium (cytokeratin AE/AE3 [A]). The corneal stroma is infiltrated with atypical squamoid cells staining positive with cytokeratin AE/AE3 (B and C). All scale bars indicate 100 μm.

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Place holder to copy figure label and caption
Figure 2.

Over the next 7 months, the corneal haze persisted (A), and vision worsened, with clinical suspicion for angle involvement. Patient underwent enucleation (B). Histopathology reveals an edematous cornea infiltrated with epithelioid cells with severe atypia staining with cytokeratin AE1/AE3 (C [scale bar, 700 μm], D [scale bar, 200 μm], and E [scale bar, 100 μm]).

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