Submitted for Publication: August 27, 2013; final revision received December 24, 2013; accepted December 29, 2013.
Published Online: April 17, 2014. doi:10.1001/jamaophthalmol.2013.8295.
Study concept and design: All authors.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: All authors.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Ding.
Obtained funding: Sullivan.
Conflict of Interest Disclosures: The authors are employees of Schepens Eye Research Institute, which has submitted a provisional patent based, in part, on the data presented herein. The authors developed the idea and generated the supportive data for this provisional patent.
Funding/Support: This study was supported by grant R01EY05612 from the National Institutes of Health; by the Margaret S. Sinon Scholar in Ocular Surface Research Fund; and by the ARVO Foundation for Eye Research /Vistakon Dry Eye Fellowship.
Role of the Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Wendy R. Kam, MS, Yang Liu, MD, and Guoxiang Ruan, PhD, Schepens Eye Research Institute, provided expert technical assistance. None of them received compensation for this contribution.