Submitted for Publication: February 26, 2014; final revision received April 15, 2014; accepted April 15, 2014.
Published Online: May 6, 2014. doi:10.1001/jamaophthalmol.2014.1871.
Study concept and design: Curcio, Spaide.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Ooto, Vongkulsiri, Curcio, Spaide.
Critical revision of the manuscript for important intellectual content: Ooto, Sato, Suzuki, Curcio, Spaide.
Statistical analysis: Ooto, Spaide.
Obtained funding: Curcio, Spaide.
Administrative, technical, or material support: Vongkulsiri, Suzuki, Spaide.
Study supervision: Curcio, Spaide.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Drs Ooto, Sato, and Suzuki reported receiving funding from Alcon Japan. Dr Curcio reported receiving grants from Genentech and Rinat Neuroscience/Pfizer and a consulting fee from Hoffman–La Roche. Dr Spaide reported receiving personal compensation from Topcon. No other disclosures were reported.
Funding/Support: This work was supported by the LuEsther T. Mertz Retinal Research Foundation. Dr Curcio is supported by National Eye Institute grant EY06109 with institutional support from the EyeSight Foundation of Alabama and Research to Prevent Blindness Inc. She also reported receiving grants from the International Retinal Research Foundation, Beckman Initiative for Macular Research, and the Edward N. and Della L. Thorne Memorial Foundation.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank Jeffrey D. Messinger, DC (Department of Ophthalmology, EyeSight Foundation of Alabama Vision Research Laboratories, University of Alabama School of Medicine, Birmingham), who prepared histology specimens and figures. Dr Messinger receives salary from National Eye Institute grant EY06109.