The clear-cell variant makes up a distinct minority of squamous cell carcinomas.1 The microscopic appearance of the clear cells can be difficult to distinguish from those of sebaceous carcinoma cells. Determining the correct diagnosis is of great therapeutic and prognostic significance, as sebaceous cell carcinoma is associated with a poorer prognosis.
Article InformationCorresponding Author: Frederick A. Jakobiec, MD, DSc, David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 (email@example.com).
Published Online: May 22, 2014. doi:10.1001/jamaophthalmol.2014.971.
Study concept and design: Jakobiec, Mandeville.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Rashid, Jakobiec.
Critical revision of the manuscript for important intellectual content: All authors.
Administrative, technical, or material support: All authors.
Study supervision: Jakobiec.
Conflict of Interest Disclosures: None reported.