Submitted for Publication: November 22, 2013; final revision received February 13, 2014; accepted February 20, 2014.
Published Online: June 12, 2014. doi:10.1001/jamaophthalmol.2014.1079.
Study concept and design: All authors.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: All authors.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Song, Williams.
Obtained funding: Williams, Chung.
Administrative, technical, or material support: Song, Latchney, Williams.
Study supervision: All authors.
Conflict of Interest Disclosures: Dr Song is collaborating with Canon, Inc on a research contract funded by Canon to help them commercialize the technology described in this report. Dr Williams is an inventor and receives royalties from licensed patents held by the University of Rochester pertaining to the adaptive optics imaging technology used in this study and is collaborating with Canon, Inc on a research contract funded by Canon to help them commercialize this technology. Dr Chung is a consultant for GlaxoSmithKline and is currently collaborating with Canon, Inc on a research contract funded by Canon to help them commercialize this technology.
Funding/Support: This work was supported in part by National Institutes of Health grants EY021786, EY014375, and EY001319; the Edward N. and Della L. Thome Memorial Foundation; the University of Rochester Clinical Trials and Science Institute award number UL1 RR024160 from the National Center for Research Resources and the National Center for Advancing Translational Sciences of the National Institutes of Health; and an unrestricted departmental grant from Research to Prevent Blindness.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Jennifer Hunter, PhD (Flaum Eye Institute and Center for Visual Science, University of Rochester), assisted with statistical analysis and Margaret Folwell, MS (Center for Visual Science, University of Rochester), assisted with image processing. The contributors did not receive financial compensation.