Complement-mediated IgA nephropathy is the most common cause of chronic glomerulonephritis worldwide. The pathogenesis of renal damage is related to complement activation secondary to IgA immune complex deposition in the glomerulus. To our knowledge, this is the first report of IgA nephropathy associated with bilateral subretinal drusenoid deposits (SDDs). A hypothesis for the role of complement is proposed.
Article InformationCorresponding Author: David R. Lally, MD, New England Eye Center, 260 Tremont St, Boston, MA 02116 (email@example.com).
Study concept and design: Lally, Baumal.
Acquisition, analysis, or interpretation of data: Lally, Baumal.
Drafting of the manuscript: Lally, Baumal.
Critical revision of the manuscript for important intellectual content: Lally, Baumal.
Statistical analysis: Lally, Baumal.
Administrative, technical, or material support: Lally.
Study supervision: Baumal.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported in part by an unrestricted award to the New England Eye Center, Tufts University School of Medicine from Research to Prevent Blindness.
Role of the Sponsor: Research to Prevent Blindness was involved in the design and conduct of the study but had no role in collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.