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Comment & Response |

Association Between Rate of Binocular Visual Field Change and Vision-Related Quality of Life—Reply

Renato Lisboa, MD1; Felipe A. Medeiros, MD, PhD1
[+] Author Affiliations
1Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla
JAMA Ophthalmol. 2014;132(6):785-786. doi:10.1001/jamaophthalmol.2014.2005.
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In Reply Mossböck and colleagues pose interesting questions regarding our study. We respectfully disagree with their claims, as outlined herein.

Mossböck and colleagues criticize the method used in our study to evaluate NEI VFQ-25 results, suggesting that we should have used the composite score. The composite score is calculated as the average of the 11 vision-target subscale scores provided by the questionnaire. This averaging is based on the assumption that these subscales measure the same underlying unidimensional construct. If such assumption is violated, it is not appropriate to report a single overall composite score. In fact, the unidimensionality of the NEI VFQ-25 has been questioned,13 and it is for this exact reason that we refrained from using a simple averaged composite score in our analysis. We therefore find the comment that “attributing equivalence to the different subscales is crude” to be supportive rather than counter to our argument, as attributing equivalence to the different subscales is exactly what the composite score does. Regardless of this, we revisited our data and regressed the logarithmic transformation of the composite score on the rates of BVF loss and found a significant relationship (P = .004).


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June 1, 2014
Writing Committee for the European Glaucoma Panel
1Ophthalmology Department, Department of Clinical Sciences, Umeå University, Umeå, Sweden
2Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland
3Postgraduate Medical Institute, Vision and Eye Research Unit, Anglia Ruskin University, Cambridge, England
JAMA Ophthalmol. 2014;132(6):784-785. doi:10.1001/jamaophthalmol.2013.8249.
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