Submitted for Publication: October 21, 2013; final revision received April 8, 2014; accepted April 11, 2014.
Published Online: July 10, 2014. doi:10.1001/jamaophthalmol.2014.1959.
Study concept and design: All authors.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Hou, Sivaraman, de la Cruz.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: de la Cruz.
Obtained funding: Hou.
Administrative, technical, or material support: Hou, Sivaraman, Lin.
Study supervision: de la Cruz, Lin, Cortina.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by an unrestricted research grant from the Illinois Society for the Prevention of Blindness.
Role of the Sponsor: The funding source was not involved in any aspect of study design or conduct; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.
Previous Presentation: Preliminary data from this study were presented at the XXX Congress of the European Society of Cataract and Refractive Surgeons; September 10, 2012; Milan, Italy.
Additional Contributions: Amy Wu, BS, and Valerie Lindgren, PhD, of the Department of Pathology, University of Illinois at Chicago, assisted with the fluorescence in situ hybridization studies. There was no financial compensation for their assistance.