Study concept and design: Bhavsar, Glassman, Jampol, Kinyoun.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: All authors.
Critical revision of the manuscript for important intellectual content: Bhavsar, Jampol, Kinyoun.
Statistical analysis: Torres, Glassman.
Obtained funding: Glassman.
Administrative, technical, or material support: Glassman, Jampol.
Study supervision: Bhavsar, Glassman, Jampol, Kinyoun.
Conflict of Interest Disclosures: Dr Bhavsar has served as a consultant for Allergan. Dr Jampol has served as a consultant for Quintiles/Stem Cell Organization. A complete list of all DRCR.net investigator financial disclosures is available at http://www.drcr.net. No other disclosures were reported.
Funding/Support: This work was supported through cooperative agreements EY1423, EY018817, and EY023207 from the National Eye Institute and the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services. Genentech provided the ranibizumab study drug for this trial and funds to the DRCR.net to defray the study’s clinical site costs.
Role of the Sponsor: The National Institutes of Health participated in oversight of the conduct of the study and review of the manuscript but not directly in the design or conduct of the study, collection, management, analysis, and interpretation of the data, or preparation of the manuscript. Genentech had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Trial Registration: clinicaltrials.gov Identifier: NCT00996437
Group Members: A complete list of the DRCR.net investigators was published in JAMA Ophthalmol. 2013;131(3):283-293.
Disclaimer: Neil M. Bressler, MD, is the JAMA Ophthalmology Editor in Chief but was not involved in the review process or the acceptance of the manuscript.
Additional Information: As described in the DRCR.net Industry Collaboration Guidelines (http://www.drcr.net), the DRCR.net had complete control over the design of the protocol, ownership of the data, and all editorial content of presentations and publications related to the protocol.
Additional Contributions: Neil M. Bressler, MD, Wilmer Eye Institute, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland, made substantial contributions to this article, including conception and design, analysis and interpretation of the data, and critical revision for important intellectual content; he received a grant from the National Institutes of Health as principal investigator of the Operations Center for work on this project.