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Research Letter |

Evaluation of Results 1 Year Following Short-term Use of Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy

Abdhish R. Bhavsar, MD1; Karisse Torres, MPH2; Adam R. Glassman, MS2; Lee M. Jampol, MD3; James L. Kinyoun, MD4; for the Diabetic Retinopathy Clinical Research Network
[+] Author Affiliations
1Retina Center of Minnesota, Minneapolis
2Jaeb Center for Health Research, Tampa, Florida
3Feinberg School of Medicine, Northwestern University, Chicago, Illinois
4University of Washington, Seattle
JAMA Ophthalmol. 2014;132(7):889-890. doi:10.1001/jamaophthalmol.2014.287.
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Vitreous hemorrhage from proliferative diabetic retinopathy can cause vision loss and preclude panretinal photocoagulation (PRP).1 The Diabetic Retinopathy Clinical Research Network (DRCR.net) investigated whether intravitreal ranibizumab compared with intravitreal saline had a beneficial effect on the vitrectomy rates of eyes with vitreous hemorrhage from proliferative diabetic retinopathy precluding complete PRP. Eyes were randomly assigned to 0.5 mg of ranibizumab (n = 125) or saline (n = 136), which was injected into the vitreous at baseline, 4 weeks, and 8 weeks.2 The primary end point was assessed at 16 weeks; for safety purposes, participants were followed for 52 weeks. After 16 weeks, each participant’s management was at the investigators’ discretion.

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Figure 1.
Cumulative Probability of Vitrectomy Surgery by 52 Weeks of Study Follow-up

Categorization of events and censoring into intervals were defined by the visit date if the visit occurred; otherwise, they were defined using the target date of the visit. The number of eyes at risk indicates those with follow-up data at the start of the interval and no vitrectomy prior to the start of the interval; the number of events indicates the number of eyes with vitrectomy during the subsequent 4-week period. No follow-up was performed between 16 and 52 weeks. NA indicates not applicable.

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Figure 2.
Cumulative Probability of Complete Panretinal Photocoagulation by 16 Weeks of Study Follow-up

Categorization of events and censoring into intervals were defined by the visit date if the visit occurred; otherwise, they were defined using the target date of the visit. Eyes with vitrectomy were censored in the interval in which the surgery occurred. The number of eyes at risk indicates those with follow-up data at the start of the interval and with no complete panretinal photocoagulation prior to the start of the interval; the number of events indicates the number of eyes with complete panretinal photocoagulation during the subsequent 4-week period. No follow-up was performed between 16 and 52 weeks. NA indicates not applicable.

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