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Research Letter |

Stability of Melphalan Solution for Intravitreal Injection for Retinoblastoma

Emiliano Buitrago, Bsc1; Eduardo Lagomarsino, PhD2; Gabriel Mato, PharmD2; Paula Schaiquevich, PhD1,3
[+] Author Affiliations
1Clinical Pharmacokinetics Unit, Hospital de Pediatría J. P. Garrahan, Buenos Aires, Argentina
2Department of Pharmacy, Hospital de Pediatría J. P. Garrahan, Buenos Aires, Argentina
3National Scientific and Technical Research Council (CONICET), Hospital de Pediatría J. P. Garrahan, Buenos Aires, Argentina
JAMA Ophthalmol. 2014;132(11):1372-1373. doi:10.1001/jamaophthalmol.2014.2324.
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Intravitreal injections for the treatment of retinoblastoma have been gaining relevance among ophthalmologists, supported by reports on outcome and improvement of the administration technique.1 Currently, doses up to 30 μg per injection are used according to an extensively described technique for intravitreal injection that minimizes the risk of extraocular dissemination of tumor cells.2

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