Submitted for Publication: December 19, 2013; final revision received February 7, 2014; accepted February 12, 2014.
Published Online: August 14, 2014. doi:10.1001/jamaophthalmol.2014.2854.
Study concept and design: Varma, Bressler, Doan, Danese, Bower, Dolan, Fine, Colman, Turpcu.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Varma, Doan, Selvin, Dolan, Fine.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Doan, Gleeson, Danese, Bower, Selvin.
Obtained funding: Danese, Fine, Turpcu.
Administrative, technical, or material support: Varma, Doan, Danese, Colman, Turpcu.
Study supervision: Selvin.
Conflict of Interest Disclosures: Dr Varma is a consultant for Allergan, Aquesys, Genentech, Inc, Merck, and Replenish; has received research funding from Genentech, Inc, and Replenish; and has an unrestricted departmental grant from Research to Prevent Blindness. Dr Bressler is principal investigator of grants or agreements at The Johns Hopkins University sponsored by the following entities: Bayer; Genentech, Inc; National Institutes of Health; Novartis Pharma AG; Regeneron Pharmaceuticals, Inc; and the Emmes Corporation. Drs Doan, Gleeson, and Danese are employees of Outcomes Insights, Inc, and paid consultants for Genentech, Inc. Drs Bower and Selvin are coinvestigators for Dr Bressler’s grant at The Johns Hopkins University, sponsored by Genentech, Inc. Dr Dolan is a paid consultant for Genentech, Inc. Drs Turpcu, Fine, and Colman are employees of Genentech, Inc.
Funding/Support: This study was supported by a grant from Genentech/Roche to The Johns Hopkins University through the Office of Research Administration of the Johns Hopkins University School of Medicine. Support for third-party editorial assistance by Rebecca Jarvis, PhD, CMPP, of Envision Scientific Solutions, was provided by Genentech, Inc. This editorial support does not meet authorship criteria per ICJME guidelines, including no involvement in study design, analysis, or drafting or critical review of the manuscript.
Role of the Sponsor: Genentech/Roche (sponsor) employees participated in the design of the study, interpretation of the data, critical revision and approval of the manuscript, and decision to submit the manuscript. They had access to the data before the completion of the data analysis but did not participate in the statistical analysis. Data management and data analysis were performed by Outcomes Insights, Inc, independent of Genentech/Roche. An independent statistical analysis was conducted by Johns Hopkins University Bloomberg School of Public Health employees (Drs Bower and Selvin).
Disclaimer: Dr Bressler is the editor of JAMA Ophthalmology. He was not involved in the editorial evaluation or the decision to accept this article for publication.
Previous Presentations: Presented in part at the 2012 Retina Society Annual Meeting; September 28, 2012; Washington, DC; and the 2012 American Academy of Optometry Annual Meeting; October 24, 2012; Phoenix, Arizona.