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Comment & Response |

Comments on Infant Aphakia Treatment Study 4.5-Year Results

Henri Sueke, FRCOphth1; Arvind Chandna, FRCOphth1
[+] Author Affiliations
1Department of Ophthalmology, Alder Hey Children’s NHS Foundation Trust, Liverpool, England
JAMA Ophthalmol. 2014;132(12):1491-1492. doi:10.1001/jamaophthalmol.2014.3532.
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To the Editor We read with interest the article on 4.5-year visual acuity outcomes for the Infant Aphakia Treatment Study (IATS).1 This is clearly a well-thought-out and meticulously devised study.

The authors state that the study follows the intention-to-treat principle. We feel that as not all the study participants met the outcome criteria, this study does not fit the definition of an intention-to-treat study, which should include all the participants. For example, only the participants who had at least 3 adherence assessments were included in the analysis.


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December 1, 2014
Scott R. Lambert, MD; Michael J. Lynn, MS; E. Eugenie Hartmann, PhD; for the Infant Aphakia Treatment Study Group
1Department of Ophthalmology, Emory Eye Center, Emory University, Atlanta, Georgia
2Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia
3Department of Visual Sciences, University of Alabama at Birmingham, Birmingham
JAMA Ophthalmol. 2014;132(12):1492-1493. doi:10.1001/jamaophthalmol.2014.3542.
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