Submitted for Publication: April 8, 2014; final revision received July 25, 2014; accepted July 26, 2014.
Published Online: October 30, 2014. doi:10.1001/jamaophthalmol.2014.4266.
Study concept and design: Riveiro-Álvarez, López-Martínez, Ayuso, Allikmets.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Riveiro-Álvarez, Xie, Pérez-Carro, Ávila-Fernández, López-Molina, Zernant, Allikmets.
Critical revision of the manuscript for important intellectual content: Riveiro-Álvarez, Xie, López-Martínez, Gambin, Jhangiani, Muzny, Yuan, Boerwinkle, Gibbs, Lupski, Ayuso, Allikmets.
Statistical analysis: Xie, Gambin.
Obtained funding: Boerwinkle, Ayuso, Allikmets.
Administrative, technical, or material support: Riveiro-Álvarez, Ávila-Fernández, López-Molina, Zernant, Jhangiani, Muzny, Boerwinkle, Gibbs, Lupski, Allikmets.
Study supervision: Riveiro-Álvarez, Muzny, Gibbs, Ayuso, Allikmets.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This work was supported in part by National Institutes of Health grants EY021163, EY019861, HG006542, and EY019007 (Core Support for Vision Research); by research grants FIS PI13/00226, FIS PS09/00459, and RD09-0076-00101 (Retics Biobank); CIBERER Intra/07/704.1 and Intra/09/702.1; ONCE; Fundaluce and Fundacion Conchita Rabago de Jimenez Diaz; and unrestricted funds from Research to Prevent Blindness to the Department of Ophthalmology, Columbia University.
Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.