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Comment & Response |

Understanding the Adverse Effects of Ocriplasmin—Reply

Michael D. Tibbetts, MD1; Elias Reichel, MD2; Andre J. Witkin, MD1
[+] Author Affiliations
1Department of Ophthalmology, Tufts Medical Center, Boston, Massachusetts
2New England Eye Center, Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts
JAMA Ophthalmol. 2015;133(2):229-230. doi:10.1001/jamaophthalmol.2014.4503.
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In Reply Beebe makes an interesting point regarding the broad substrate specificity of ocriplasmin (JETREA). He points out that ocriplasmin is derived from plasmin, which cleaves proteins at the same basic amino acids. There are likely many additional substrates that are not listed in the JETREA package insert. The cleavage of these unknown substrates by ocriplasmin may contribute to the structural and functional effects on the retina outlined in our article and by Fahim et al.1

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February 1, 2015
David C. Beebe, PhD
1Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
JAMA Ophthalmol. 2015;133(2):229. doi:10.1001/jamaophthalmol.2014.4484.
February 1, 2015
Mark W. Johnson, MD; Abigail T. Fahim, MD, PhD
1Department of Ophthalmology and Visual Sciences, W. K. Kellogg Eye Center, University of Michigan Medical School, Ann Arbor
JAMA Ophthalmol. 2015;133(2):230. doi:10.1001/jamaophthalmol.2014.4505.
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