Submitted for Publication: May 16, 2014; final revision received September 11, 2014; accepted September 19, 2014.
Published Online: November 6, 2014. doi:10.1001/jamaophthalmol.2014.4498.
Study concept and design: Blanco-Kelly, Ayuso.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Blanco-Kelly, López-Molina, Millán, Ayuso.
Critical revision of the manuscript for important intellectual content: Blanco-Kelly, Jaijo, Aller, Avila-Fernandez, Giménez, García-Sandoval, Ayuso.
Statistical analysis: Blanco-Kelly.
Administrative, technical, or material support: Aller, López-Molina, Giménez, García-Sandoval.
Study supervision: Blanco-Kelly, Giménez, Millán, Ayuso.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This work was supported by grant PI13/00226 (to Servicio de Genética, Instituto de Investigación–Fundación Jiménez Díaz, Madrid, Spain), by grant PI13/00638 (to Unidad de Genética y Diagnóstico Prenatal, Hospital Universitario y Politécnico La Fe, Valencia, Spain), and by grant 06/07/0036 (to Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain) from Fundaluce and Organización Nacional de Ciegos Españoles.
Role of the Funder/Sponsor: The funding sponsor had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank Ignacio Mahillo, PhD, at Instituto de Investigación–Fundación Jiménez Díaz for his advice and help on performing statistical analysis and Oliver Shaw, BSc, at Instituto de Investigación–Fundación Jiménez Díaz for his invaluable help in the English revision of the manuscript. Any compensation for such contributions was received from the funding sponsor.