Submitted for Publication: June 2, 2014; final revision received September 22, 2014; accepted September 27, 2014.
Published Online: November 20, 2014. doi:10.1001/jamaophthalmol.2014.4747.
Study concept and design: Borrás, Buie.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Borrás, Buie, Carabana.
Critical revision of the manuscript for important intellectual content: Borrás, Buie, Spiga.
Statistical analysis: Borrás, Buie.
Obtained funding: Borrás.
Administrative, technical, or material support: Borrás, Buie.
Study supervision: Borrás.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest, and none were reported.
Funding/Support: This study was funded by grants EY11906 and EY13126 from the National Eye Institute (Dr Borrás) and in part by a Research to Prevent Blindness unrestricted grant to the Department of Ophthalmology, University of North Carolina at Chapel Hill.
Role of the Funder/Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Renekia R. Elliott, BA, Matthew H. Smith, BS, and Brandon M. Lane, PhD, members of our laboratory, provided continuous input and support during the project.