We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
In This Issue of JAMA Ophthalmology |

Highlights FREE

JAMA Ophthalmol. 2014;132(12):1389. doi:10.1001/jamaophthalmol.2013.5973.
Text Size: A A A
Published online


Gandolfi and colleagues evaluate the role of drug-induced mydriasis and laser peripheral iridotomy to manage patients with pigment dispersion syndrome in a randomized clinical trial. In their high-risk group, 3 of 21 eyes that underwent laser peripheral iridotomy (14.3%) and 13 of 21 untreated eyes (61.9%) showed an increase in intraocular pressure of 5 mm Hg or higher during the follow-up period (P < .001 for treated high-risk eyes vs untreated high-risk eyes). The results suggest that laser peripheral iridotomy on high-risk eyes can be protective over the long term.

Because residential (geographic) history and extent of solar exposure may be important risk factors for exfoliation syndrome (XFS), Pasquale and colleagues assess the relation between residential history, solar exposure, and XFS in a clinic-based case-control study in the United States and Israel. In multivariable analyses, each degree of weighted lifetime average residential latitude away from the equator was associated with 11% increased odds of XFS (pooled odds ratio, 1.11; 95% CI, 1.05-1.17; P < .001), and every hour per week spent outdoors during the summer, averaged over a lifetime, was associated with 4% increased odds of XFS (pooled odds ratio, 1.04; 95% CI, 1.00-1.07; P = .03). The authors concluded that lifetime outdoor activities may contribute to XFS.

The risk for irreversible toxic retinopathy from hydroxychloroquine sulfate may be much higher because retinopathy can be detected earlier using more sensitive screening techniques. Melles and Marmor reassess the prevalence of and risk factors for hydroxychloroquine retinal toxicity in a retrospective case-control study within an integrated health organization of approximately 3.4 million members among 2361 patients who had used hydroxychloroquine continuously for at least 5 years and were evaluated with visual field testing or spectral-domain optical coherence tomography. The overall prevalence of hydroxychloroquine retinopathy was 7.5% but varied with daily consumption (odds ratio, 5.67; 95% CI, 4.14-7.79 for >5.0 mg/kg) and with duration of use (odds ratio, 3.22; 95% CI, 2.20-4.70 for >10 years). The data suggest that hydroxychloroquine retinopathy is more common than previously recognized, especially at high dosages and long duration of use.

As spectacle independence is becoming increasingly important in cataract surgery, Visser and colleagues compare bilateral aspherical toric with bilateral aspherical control intraocular lens (IOL) implantation among 86 individuals with cataract and corneal astigmatism in a randomized clinical trial. At 6 months postoperatively, 26 (70%) of the patients in the toric group achieved an uncorrected distance visual acuity of 20/25 or better compared with 14 (31%) in the control group (P < .001; odds ratio, 5.23; 95% CI, 2.03-13.48), while spectacle independency for distance vision was achieved in 31 patients (84%) in the toric group compared with 14 (31%) in the control group (P < .001; odds ratio, 11.44; 95% CI, 3.89-33.63). The authors concluded that for patients with cataract and corneal astigmatism, bilateral toric IOL implantation results in a higher spectacle independency for distance vision compared with bilateral control IOL implantation.





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Related Content

Customize your page view by dragging & repositioning the boxes below.