Submitted for Publication: September 5, 2014; final revision received October 27, 2014; accepted October 27, 2014.
Published Online: December 18, 2014. doi:10.1001/jamaophthalmol.2014.5168.
Study concept and design: Almeida, Chin, Mullins, Folk, Abràmoff, Russell.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Almeida, Chin, Abràmoff.
Critical revision of the manuscript for important intellectual content: Almeida, Zhang, Mullins, Kucukevcilioglu, Critser, Sonka, Stone, Folk, Abràmoff, Russell.
Statistical analysis: Almeida, Zhang.
Obtained funding: Mullins, Sonka, Abràmoff, Russell.
Administrative, technical, or material support: Almeida, Zhang, Chin, Kucukevcilioglu, Critser, Sonka, Stone, Russell.
Study supervision: Almeida, Mullins, Sonka, Folk, Abràmoff, Russell.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Mullins reported receiving honorarium from Imagen Bio outside of this study. Dr Sonka holds US patents related to image segmentation in N-dimensional space. Dr Abràmoff reported receiving support from IDx LLC. Dr Abràmoff also has patents for image segmentation in N-dimensional space and patents licensed to IDx LLC. No other disclosures were reported.
Funding/Support: Dr Sonka has received grants from the National Institutes of Health. Dr Abràmoff has received grants from the National Institutes of Health and the Arnold and Mabel Beckman Initiative for Macular Research, as well as other support from the American Diabetes Association and the University of Iowa.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.