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In This Issue of JAMA Ophthalmology |

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JAMA Ophthalmol. 2015;133(1):5. doi:10.1001/jamaophthalmol.2014.3697.
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RESEARCH

This retrospective observational pilot study by Burgmeier and colleagues among 33 participants suggests that children with a history of amblyopia have impaired visual-auditory speech perception. Early childhood appears to serve as an approximate time point for the development of successful visual-auditory fusion, by which time amblyopia must have either resolved or begun. Interventions to resolve amblyopia may not only influence visual acuity, but may also influence the perception of sound.

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This independent assessment of 8 ophthalmologic conditions in the Cochrane Database of Systematic Reviews found that certain conditions get more focus to create a better representation of what is causing the most disability and mortality within this research database. Comparing the number of reviews and protocols with disability, Boyers and colleagues found that only cataract was well matched; glaucoma, macular degeneration, and other vision loss were overrepresented. In comparison, trachoma, onchocerciasis, vitamin A deficiency, and refraction and accommodation disorders were underrepresented. These results provide high-quality and transparent data that may help to inform future ophthalmologic research prioritization decisions.

This prospective study by Yannuzzi and colleagues of syringes containing 21 intravitreous preparations of bevacizumab (Avastin) from 11 pharmacies found that such repackaged or compounded preparations were negative for microbial contaminants and endotoxin. However, there were variations in protein concentration that appeared to be lower than in the bevacizumab acquired from the manufacturer. Seventeen samples (81%) had lower protein concentrations (mean [SD], 22.2 [4.9] mg/mL; range, 19.2-24.5 mg/mL) compared with bevacizumab acquired directly from the manufacturer (25 mg/mL). In 3 of 10 pharmacies where more than 1 sample was available, differences in the protein concentration between samples from the same pharmacy were identified. The clinical implications of these variable protein levels remain uncertain.

This retrospective study from Pineles and colleagues determined that Medicare beneficiaries with a disorder of binocular vision have higher odds of sustaining a musculoskeletal injury, fracture, or fall. Among 2 196 881 Medicare beneficiaries identified, the adjusted odds ratio for the association between disorders of binocular vision and any of the 3 injury types was 1.27 (95% CI, 1.25-1.29; P < .001). This finding may be an important step forward in understanding and developing strategies to prevent these injuries, which are associated with high morbidity in this cohort.

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