Submitted for Publication: September 5, 2014; final revision received December 15, 2014; accepted December 23, 2014.
Published Online: February 12, 2015. doi:10.1001/jamaophthalmol.2014.6115.
Study concept and design: Shankar, Birch, Bowne, Daiger.
Acquisition, analysis, or interpretation of data: Shankar, Birch, Ruiz, Hughbanks-Wheaton, Sullivan, Bowne, Stone.
Drafting of the manuscript: Shankar, Birch, Hughbanks-Wheaton, Sullivan, Daiger.
Critical revision of the manuscript for important intellectual content: Shankar, Birch, Ruiz, Hughbanks-Wheaton, Bowne, Stone, Daiger.
Statistical analysis: Shankar, Daiger.
Obtained funding: Birch, Stone, Daiger.
Administrative, technical, or material support: Shankar, Birch, Hughbanks-Wheaton, Bowne, Stone, Daiger.
Study supervision: Shankar, Birch, Sullivan, Bowne, Stone, Daiger.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Shankar currently serves as medical director for the Emory Genetics Laboratory. No other disclosures were reported.
Funding/Support: This work was supported by grants from the Foundation Fighting Blindness, the William Stamps Farish Foundation, the Hermann Eye Fund, and grant EY007142 from the National Institutes of Health. Research to Prevent Blindness provided an unrestricted grant to the Department of Ophthalmology at Emory University.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank Gerald Fishman, MD, Center for Inherited Retinal Disease, Jonathon Sears, MD, Cole Eye Institute, and Richard Weleber, MD, Casey Eye Institute, for providing access to patients and clinical information. We are grateful to Jean Andorf, BA, a research assistant at the Stephen A. Wynn Institute for Vision Research, for excellent technical assistance and data review. None of these individuals received financial compensation for their contributions.