Submitted for Publication: October 1, 2014; final revision received December 29, 2014; accepted December 30, 2014.
Published Online: March 12, 2015. doi:10.1001/jamaophthalmol.2015.0319.
Study concept and design: Prajna, Krishnan, Srinivasan, Oldenburg, McLeod, Lietman, Acharya.
Acquisition, analysis, or interpretation of data: Rose-Nussbaumer, Mascarenhas, Rajaraman, Raghavan, Oldenburg, O’Brien, Ray, Porco, Acharya, Keenan.
Drafting of the manuscript: Rose-Nussbaumer.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Rose-Nussbaumer, Prajna, Srinivasan, Ray, Porco, Keenan.
Obtained funding: Oldenburg, Acharya.
Administrative, technical, or material support: Krishnan, Mascarenhas, Rajaraman, Raghavan, Oldenburg, O’Brien, McLeod, Lietman, Acharya.
Study supervision: Lietman, Acharya.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest, and Ms O’Brien reports having received grants from the NEI during the conduct of the study. No other disclosures were reported.
Funding/Support: The research portion of our study was financially supported by the NEI, in conjunction with the NEI-sponsored MUTT I (grant U10-EY018573-01A1 to Dr Lietman, principal investigator).
Role of the Funder/Sponsor: The funder/sponsor had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information:Clinical Centers: Aravind Eye Hospital, Madurai, Tamil Nadu, India: N. Venkatesh Prajna, MD (principal investigator), Prajna Lalitha, MD, Jeena Mascarenhas, MD, Muthiah Srinivasan, MD, FRCOphth, MA, Rajarathinam Karpagam, Malaiyandi Rajkumar, S. R. Sumithra, C. Sundar; Aravind Eye Hospital, Coimbatore, Tamil Nadu, India: Revathi Rajaraman, MD (site director), Anita Raghavan, MD, P. Manikandan, MPhil; Aravind Eye Hospital, Pondicherry, Tamil Nadu, India: K. Tiruvengada Krishnan, MD (site director), N. Shivananda; Francis I. Proctor Foundation, University of California, San Francisco: Thomas M. Lietman, MD (principal investigator), Nisha R. Acharya, MD, MS (principal investigator), Stephen D. McLeod, MD, John P. Whitcher, MD, MPH, Salena Lee, OD, Vicky Cevallos, MT(ASCP), Brett L. Shapiro, MD, Catherine E. Oldenburg, MPH, Kieran S. O’Brien, MPH, Kevin C. Hong, BA. Data and Safety Monitoring Committee: Marian Fisher, PhD (chair), Anthony Aldave, MD, Donald Everett, MA, Jacqueline Glover, PhD, K. Ananda Kannan, MD, Steven Kymes, PhD, and Ivan Schwab, MD. Resource Centers: Coordinating Center, Francis I. Proctor Foundation, University of California, San Francisco: Thomas M. Lietman, MD (principal investigator), Nisha R. Acharya, MD, MS (principal investigator), David Glidden, PhD, Stephen D. McLeod, MD, John P. Whitcher, MD, MPH, Salena Lee, OD, Kathryn Ray, MA, Vicky Cevallos, MT(ASCP), Brett L. Shapiro, MD, Catherine E. Oldenburg, MPH, Kevin C. Hong, BA, Kieran S. O’Brien, MPH; Project Office, NEI, Rockville, Maryland: Donald F. Everett, MA; Photography Reading Center, Dartmouth Medical School, Lebanon, New Hampshire: Michael E. Zegans, MD, and Christine M. Kidd, PhD.