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Pigmented Limbal Nodule Consistent With a Ciliary Body Nevus in an Organ Donor

Ebba Nissen, MD1; John Armitage, PhD2; Sophie Thornton, BSc1; Sarah E. Coupland, MBBS, PhD, FRCPath1
[+] Author Affiliations
1Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, England
2Department of Ophthalmology, CTS Eye Bank, Bristol, England
JAMA Ophthalmol. 2015;133(6):721-723. doi:10.1001/jamaophthalmol.2015.214.
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With the exception of melanocytomas, ciliary body nevi are rare. Previous case series have reported episcleral nodular extension of ciliary body nevi leading to their diagnosis1 or alternatively ciliary body nevi with involvement of the iris root, resulting in their detection using slitlamp biomicroscopy.2 Herein, we report a pigmented limbal nodule consistent with a ciliary body nevus diagnosed post mortem in a donor eye as an incidental finding during corneoscleral disc preparation for transplantation.

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Figure 1.
Histopathological Analysis of the Ciliary Body Nevus

A, Corneoscleral disc showing ciliary body nevus with transscleral extension into the episclera (original magnification ×3.4, hematoxylin-eosin). The area outlined by the box is shown in B. B, Intrascleral extension of bland nevus cells (original magnification ×40, hematoxylin-eosin). C, Melan A–positive nevus cells in the episcleral nodule (original magnification ×3.4, 3,3'-diaminobenzidine immunostaining). D, S-100 protein–positive nevus cells (original magnification ×40, 3,3'-diaminobenzidine immunostaining).

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Figure 2.
Results of Multiplex Ligation-Dependent Probe Amplification of the Ciliary Body Nevus

Results of multiplex ligation-dependent probe amplification of the ciliary body nevus. The loci examined are indicated by their gene names on the x-axis. The parallel dashed lines indicate the range within which the loci are considered to be normal for uveal melanoma. The overall status for chromosomes 1p, 3, 6, and 8 was considered to be normal for this case.

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