Submitted for Publication: December 22, 2014; final revision received February 5, 2015; accepted February 13, 2015.
Published Online: April 16, 2015. doi:10.1001/jamaophthalmol.2015.0726.
Study concept and design: Rosenbaum, Choi, Harrington, Tse, Selva, Planck.
Acquisition, analysis, or interpretation of data: Rosenbaum, Choi, Wilson, Grossniklaus, Harrington, Sibley, Ng, Steele, Czyz, Foster, Tse, Alabiad, Dubovy, Parekh, Harris, Kazim, Patel, White, Dolman, Korn, Kikkawa, Edward, Alkatan, al-Hussain, Yeatts, Selva, Stauffer, Planck.
Drafting of the manuscript: Rosenbaum, Choi, Wilson, Harrington, Sibley, Tse, Stauffer, Planck.
Critical revision of the manuscript for important intellectual content: Rosenbaum, Choi, Grossniklaus, Harrington, Dailey, Ng, Steele, Czyz, Foster, Tse, Alabiad, Dubovy, Parekh, Harris, Kazim, Patel, White, Dolman, Korn, Kikkawa, Edward, Alkatan, al-Hussain, Yeatts, Selva, Planck.
Statistical analysis: Choi, Sibley, Tse, Parekh.
Obtained funding: Rosenbaum, Choi, Planck.
Administrative, technical, or material support: Rosenbaum, Wilson, Grossniklaus, Harrington, Sibley, Dailey, Steele, Alabiad, Dubovy, Kazim, White, Dolman, Korn, Kikkawa, Alkatan, al-Hussain, Stauffer, Planck.
Study supervision: Rosenbaum, Harrington, Korn, Selva, Planck.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Rosenbaum has consulted for Genentech and was a coinvestigator on a study funded by Genentech to evaluate the use of rituximab for orbital inflammatory diseases. No other disclosures were reported.
Funding/Support: This study was supported in part by grants EY020249, EY010572, and RR024140 from the National Health Institute and by Research to Prevent Blindness, the William and Mary Bauman Foundation, the Mas Family Foundation, and the Stan and Madelle Rosenfeld Family Trust.
Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Previous Presentations: Some of these data have been presented at the annual meetings of the Association for Research in Vision and Ophthalmology; May 6, 2013; Seattle, Washington, and May 7, 2014; Orlando, Florida, and also at the 2014 annual meeting of the American College of Rheumatology; November 17, 2014; Boston, Massachusetts. The raw and normalized gene expression microarray data have been uploaded to the GEO database.
Additional Contributions: RNA extraction and microarray assays were performed in the Oregon Health & Science University Gene Profiling Shared Resource. Kristina Vartanian, BS, Integrated Genomics Laboratory, Oregon Health & Science University, provided excellent technical support for the microarray work. There was no financial compensation.