Submitted for Publication: November 23, 2014; final revision received February 25, 2015; accepted March 1, 2015.
Published Online: April 16, 2015. doi:10.1001/jamaophthalmol.2015.0814.
Study concept and design: Both authors.
Acquisition, analysis, or interpretation of data: Both authors.
Drafting of the manuscript: Both authors.
Critical revision of the manuscript for important intellectual content: Both authors.
Statistical analysis: Both authors.
Obtained funding: Seddon.
Administrative, technical, or material support: Seddon.
Study supervision: Seddon.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Ferrara is an employee of Genentech Inc and has equity/options from Roche. No other disclosures were reported.
Funding/Support: This study was supported by grants RO1-EY11309 and RO1-EY022445 from the National Institutes of Health; the Massachusetts Lions Eye Research Fund Inc, New Bedford; unrestricted grants from Research to Prevent Blindness Inc, New York, New York; Foundation Fighting Blindness, Columbia, Maryland; the American Macular Degeneration Foundation, Northampton, Massachusetts; and the Age-Related Macular Degeneration Research Fund, Ophthalmic Epidemiology and Genetics Service, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We appreciate the assistance of Bernard Rosner, PhD, Channing Division of Network Medicine, Harvard Medical School, and Rachel E. Silver, MPH, Ophthalmic Epidemiology and Genetics Service, Tufts Medical Center, with programming and analyses. They received compensation for their contributions from the National Institutes of Health (RO1-EY11309) and the Age-Related Macular Degeneration Research Fund, Ophthalmic Epidemiology and Genetics Service, Tufts Medical Center, Tufts University School of Medicine.