Submitted for Publication: December 15, 2014; final revision received February 27, 2015; accepted March 1, 2015.
Published Online: April 30, 2015. doi:10.1001/jamaophthalmol.2015.0900.
Study concept and design: Torbidoni, Gabri, de Dávila, D. F. Alonso, Chantada.
Acquisition, analysis, or interpretation of data: Laurent, Sampor, Ottaviani, Vazquez, Rossi, C. Alonso, D. F. Alonso, Chantada.
Drafting of the manuscript: Torbidoni, Laurent, Sampor, Ottaviani, Rossi, de Dávila, C. Alonso, Chantada.
Critical revision of the manuscript for important intellectual content: Laurent, Vazquez, Gabri, D. F. Alonso.
Statistical analysis: Torbidoni, Laurent, C. Alonso.
Obtained funding: Torbidoni, D. F. Alonso, Chantada.
Administrative, technical, or material support: Laurent, Ottaviani.
Study supervision: Torbidoni, Gabri, de Dávila, D. F. Alonso, Chantada.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Drs Torbidoni, Gabri, and D. F. Alonso are members of Consejo Nacional de Investigaciones Científicas y Técnicas. No other disclosures were reported.
Funding/Support: This study was supported by the Fund for Ophthalmic Knowledge, the Natalí Dafne Flexer Foundation, Instituto Nacional del Cáncer, and grant BID-PID129-PAE37.011 from Agencia Nacional de Promoción Científica y Tecnológica.
Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Xiaoliang Leon Xu, MD, PhD (Department of Surgery, Memorial Sloan Kettering Cancer Center), and Carmen de Torres, MD, PhD (Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu), provided expert advice on the design of this study. Nai Kong Cheung, MD, PhD (Department of Pediatrics, Memorial Sloan Kettering Cancer Center), supplied the 3F8 antibody. These contributors did not receive financial compensation.