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Bilateral Choroidopathy and Serous Retinal Detachments During Ipilimumab Treatment for Cutaneous Melanoma

Dimosthenis Mantopoulos, MD1; Kari L. Kendra, MD, PhD2; Alan D. Letson, MD1; Colleen M. Cebulla, MD, PhD1
[+] Author Affiliations
1Havener Eye Institute, Department of Ophthalmology and Visual Science, The Ohio State University, Wexner Medical Center, Columbus
2Department of Internal Medicine, Division of Medical Oncology, The Ohio State University, Wexner Medical Center, Columbus
JAMA Ophthalmol. 2015;133(8):965-967. doi:10.1001/jamaophthalmol.2015.1128.
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Several immune-related toxic effects have been reported with ipilimumab therapy for cutaneous melanoma. We describe a novel reaction, to our knowledge, involving the choroidal vasculature and resulting in bilateral serous retinal detachments without overt inflammatory signs.

Article InformationCorresponding Author: Colleen M. Cebulla, MD, PhD, Havener Eye Institute, Department of Ophthalmology and Visual Science, The Ohio State University, 915 Olentangy River Rd, Ste 5000, Columbus, OH 43212 (colleen.cebulla@osumc.edu).

Published Online: May 14, 2015. doi:10.1001/jamaophthalmol.2015.1128.

Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

Funding/Support: This work was supported by grant K08EY022672 from the National Eye Institute and by the Ohio Lions Eye Research Foundation and the Patti Blow Fund. ECOG 1609 provided drug and support for the clinical trial.

Role of the Funder/Sponsor: The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

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Serous Detachments and Choroidopathy After Ipilimumab Therapy

A-E, Color fundus photograph (A), autofluorescence photograph (B), spectral-domain optical coherence tomographic image (N indicates nasal; S, superior, and T, temporal) (C), fluorescein angiographic image (D), and indocyanine green angiographic image (E) before dexamethasone treatment. D, The fluorescein lacks abnormal hyperfluorescence. E, Arrowheads indicate staining of small and midsized choroidal vessels; box, area shown in G. F, Spectral-domain optical coherence tomographic image following dexamethasone treatment (T indicates temporal; pink line, foveal center). G, Magnified inset from E showing indocyanine green staining of small and midsized choroidal vessels (arrowheads).

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