Submitted for Publication: December 3, 2014; final revision received April 14, 2015; accepted April 23, 2015.
Published Online: June 18, 2015. doi:10.1001/jamaophthalmol.2015.1823.
Study concept and design: Aref, Scott, VanVeldhuisen.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Aref, Scott, Oden, VanVeldhuisen.
Critical revision of the manuscript for important intellectual content: Aref, Scott, Ip, Blodi, VanVeldhuisen.
Statistical analysis: Oden, Ip, VanVeldhuisen.
Obtained funding: Blodi, VanVeldhuisen.
Administrative, technical, or material support: Aref, VanVeldhuisen.
Study supervision: Aref, Blodi, VanVeldhuisen.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Ip reported receiving personal fees from Alimera and Thrombogenics. Dr VanVeldhuisen reported receiving grants and nonfinancial support from Allergan Inc. No other disclosures were reported.
Funding/Support: The SCORE Study was funded by the National Eye Institute (National Institutes of Health, Department of Health and Human Services) grants 5U10EY014351, 5U10EY014352, and 5U10EY014404. Financial support was also provided in part by Allergan Inc through donation of investigational drug and partial funding of site monitoring visits and secondary data analyses. Dr Aref is supported by National Institutes of Health Core Grant EY001792 and an unrestricted grant from Research to Prevent Blindness in preparation of this article. Drs Scott and VanVeldhuisen have received grant support from the National Eye Institute.
Role of the Funder/Sponsor: Neither Allergan Inc nor Research to Prevent Blindness played any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Because the trial was funded by the National Eye Institute/National Institutes of Health under a cooperative agreement, a National Eye Institute program director participated in SCORE Study committees and assisted but did not direct study leadership in the design, implementation, and execution of the SCORE Study.
Group Information: The SCORE Study Investigator Group members are listed in the eAppendix in the Supplement.