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Comparative Effectiveness Trial for Diabetic Macular Edema Three Comparisons for the Price of 1 Study From the Diabetic Retinopathy Clinical Research Network

Lee M. Jampol, MD1; Adam R. Glassman, MS2; Neil M. Bressler, MD3,4
[+] Author Affiliations
1Feinberg School of Medicine, Northwestern University, Chicago, Illinois
2Jaeb Center for Health Research, Tampa, Florida
3Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
4Editor in Chief, JAMA Ophthalmology
JAMA Ophthalmol. 2015;133(9):983-984. doi:10.1001/jamaophthalmol.2015.1880.
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This Viewpoint discusses the early findings of the Diabetic Retinopathy Clinical Research Network, which is comparing the effectiveness of aflibercept, bevacizumab, and ranibizumab in patients with diabetic macular edema.

Thickening of the center of the retina from diabetes mellitus, diabetic macular edema (DME), is a common cause of vision impairment and blindness in the United States.1 Diabetic macular edema is associated with increased intraocular levels of vascular endothelial growth factor (VEGF).2 Vascular endothelial growth factor also can cause proliferation of new vasculature on the surface of the retina (neovascularization of the disc or elsewhere), termed proliferative diabetic retinopathy. Left untreated, DME or proliferative diabetic retinopathy may damage the retina, causing substantial vision loss.

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