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Brief Report |

Association of Rivaroxaban Anticoagulation and Spontaneous Vitreous Hemorrhage

Judy H. Jun, BS1; John C. Hwang, MD, MBA1,2
[+] Author Affiliations
1Retina Associates of Orange County, Laguna Hills, California
2University of Southern California, Eye Institute, Keck School of Medicine, Los Angeles
JAMA Ophthalmol. 2015;133(10):1184-1186. doi:10.1001/jamaophthalmol.2015.2069.
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Importance  Rivaroxaban is an anticoagulant prescribed for the management of atrial fibrillation. We describe a correlation between rivaroxaban and spontaneous vitreous hemorrhage.

Observations  Three patients developed spontaneous vitreous hemorrhage after initiating rivaroxaban anticoagulation. All 3 patients were taking an additional anticoagulant at the time of hemorrhage.

Conclusions and Relevance  Rivaroxaban is increasingly prescribed as a replacement for warfarin sodium in the management of atrial fibrillation. Rivaroxaban anticoagulation may be associated with spontaneous vitreous hemorrhage. The risk of hemorrhage may be particularly elevated during the transition period when patients are switched from baseline anticoagulant to rivaroxaban therapy and are taking both anticoagulants simultaneously.

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