Submitted for Publication: March 16, 2015; final revision received May 29, 2015; accepted May 29, 2015.
Published Online: July 16, 2015. doi:10.1001/jamaophthalmol.2015.2239.
Study concept and design: R. Klein.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: R. Klein.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Myers, Lee, Cruickshanks, Gangnon.
Obtained funding: R. Klein, Cruickshanks, B. E. K. Klein.
Administrative, technical, or material support: Paterson, B. E. K. Klein.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This research was supported by grant EY016379 from the National Institutes of Health (Drs R. Klein and B. E. K. Klein) and an unrestricted grant from Research to Prevent Blindness, New York, New York.
Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily reflect the official views of the National Eye Institute or the National Institutes of Health.
Previous Presentation: An abstract of this paper was presented at the Annual Meeting of the Association for Research and Vision in Ophthalmology; May 7, 2014; Orlando, Florida.
Additional Contributions: Heidi M. G. Christian, BA, and Erin L. Syth, MS, of the Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, assisted with the technical editing and preparation of the manuscript. They received no additional compensation beyond their normal wages as employees of the University of Wisconsin for their assistance.