We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Observation |

Memantine-Associated Corneal Endothelial Dysfunction

Matthew T. Feng, MD1; Francis W. Price Jr, MD1; Yuri McKee, MD1; Marianne O. Price, PhD2
[+] Author Affiliations
1Price Vision Group, Indianapolis, Indiana
2Cornea Research Foundation of America, Indianapolis, Indiana
JAMA Ophthalmol. 2015;133(10):1218-1220. doi:10.1001/jamaophthalmol.2015.2476.
Text Size: A A A
Published online


This case report describes corneal endothelial dysfunction in a patient being treated with memantine for Alzheimer disease.

Alzheimer disease (AD) is the most common type of dementia and a growing public health concern. Its estimated prevalence in the United States is 5.2 million cases and is projected to exceed 13 million cases by 2050.1 With no cure available, therapy is palliative via modulation of acetylcholine and glutamate. Current treatment patterns favor cholinesterase inhibitors and N-methyl-d-aspartate (NMDA) receptor antagonists, respectively.2

Figures in this Article

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Figure 1.
Diagram Juxtaposing the Adamantanes

The chemical structures of amantadine (A) and its congener memantine (B), which possesses additional methyl groups (red) at the 3- and 5-carbon positions. NH2 indicates amine group.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Optical Coherence Tomographic Images of the Patient’s Right Eye Showing 3 Consecutive Descemet Membrane Endothelial Keratoplasty Grafts From Unrelated Donors

A-C, While the patient was being treated with memantine, all grafts were diffusely detached (arrowheads) on their respective second postoperative days. Multiple air injections failed prior to memantine washout. D, After memantine washout and intracameral air injection, the third graft (C) attached and edema resolved in the recipient (D).

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections

Care at the Close of Life: Evidence and Experience
Alzheimer Disease: "It's OK, Mama, If You Want to Go, It's OK"

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Supplemental Content