Aref and colleagues for the SCORE Study Investigator Group investigate the incidence, risk factors, and time course of intraocular pressure (IOP) elevation in participants in a secondary analysis from the SCORE Study, a randomized clinical trial of 682 patients with macular edema secondary to retinal vein occlusion assigned to standard care, 1 mg of intravitreous triamcinolone acetonide (IVTA), or 4 mg of IVTA therapy. Kaplan-Meier incidences of IOP elevation greater than 10 mm Hg from baseline at 36 months were 0.02, 0.09, and 0.45 in the standard care, 1-mg IVTA, and 4-mg IVTA groups, respectively. Some IOP-related events took several months from the time of first IVTA injection to occur. Risk factors for an IOP-related event included higher treatment dose, younger age, and higher baseline IOP. The authors noted that clinicians should be mindful of these risk factors when assessing the risks and benefits of IVTA therapy.