0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Invited Commentary |

Conjunctival Melanoma—Clinical Pearls Now, Hope for the Future

Dan S. Gombos, MD1
[+] Author Affiliations
1Section of Ophthalmology, Department of Head and Neck Surgery, MD Anderson Cancer Center, Houston, Texas
JAMA Ophthalmol. 2015;133(11):1303-1304. doi:10.1001/jamaophthalmol.2015.3564.
Text Size: A A A
Published online

Extract

In this issue of JAMA Ophthalmology, Larsen and colleagues1 performed a retrospective review of primary conjunctival melanomas; the cohort represented a 50-year retrospective assessment of specimens identified in the Eye Pathology Institute at the University of Copenhagen. The authors performed an analysis looking for BRAF mutation in all specimens when available. The main outcome measures included local and regional recurrences as well as melanoma-related mortality. The volume of cases in this report is impressive with 139 patients reviewed and a subset of 47 tumors analyzed for BRAF mutation. The study confirmed previous findings with regard to location—extrabulbar conjunctival melanomas are associated with the worst prognosis. The study did not identify or correlate tumor thickness, which has been identified as an important risk factor for regional spread. Nor did the authors address in depth the significance of primary acquired melanosis as a risk factor for development of frank melanoma. The latter are 2 very important features that surgeons should consider in their treatment strategy and stratification of high-risk patients.

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

359 Views
1 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
Jobs
brightcove.createExperiences();