0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Progressively Increased Variation in Tear Osmolarity Mirrors Dry Eye Severity—Reply

Vatinee Y. Bunya, MD1; Maxwell Pistilli, MEd, MS1; Gui-Shuang Ying, PhD1
[+] Author Affiliations
1Scheie Eye Institute, University of Pennsylvania, Philadelphia
JAMA Ophthalmol. 2015;133(12):1482. doi:10.1001/jamaophthalmol.2015.3860.
Text Size: A A A
Published online

Extract

In Reply Our study does not invalidate the utility of tear osmolarity as a biomarker of ocular surface disease, but rather raises questions about the clinical utility of measuring osmolarity using the TearLab system owing to the high variability of measurements at a single session and across sessions in both patients with dry eye and controls.1 We agree that there is substantial evidence regarding tear instability and hyperosmolarity in the pathophysiology of dry eye disease; however, much of the previously published research used different methods of measurement rather than electrical impedance as used in the TearLab system.

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

December 1, 2015
Benjamin D. Sullivan, PhD; Jay S. Pepose, MD, PhD; Gary N. Foulks, MD
1TearLab Corporation, San Diego, California
2Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
3Department of Ophthalmology and Visual Sciences, University of Louisville, Kentucky
JAMA Ophthalmol. 2015;133(12):1481-1482. doi:10.1001/jamaophthalmol.2015.3854.
December 1, 2015
Laura E. Downie, BOptom, PhD, PGCertOcTher, DipMus(Prac), AMusA, FACO; Algis J. Vingrys, BSc(Optom), PhD, PGCertOcTher
1Department of Optometry and Vision Sciences, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Australia
JAMA Ophthalmol. 2015;133(12):1480. doi:10.1001/jamaophthalmol.2015.3856.
December 1, 2015
James V. Aquavella, MD
1University of Rochester Flaum Eye Institute, Rochester, New York
JAMA Ophthalmol. 2015;133(12):1482-1483. doi:10.1001/jamaophthalmol.2015.3863.
December 1, 2015
Vatinee Y. Bunya, MD; Maxwell Pistilli, MEd, MS; Mina Massaro-Giordano, MD
1Scheie Eye Institute, University of Pennsylvania, Philadelphia
JAMA Ophthalmol. 2015;133(12):1480-1481. doi:10.1001/jamaophthalmol.2015.3858.
December 1, 2015
Vatinee Y. Bunya, MD; Maxwell Pistilli, MEd, MS; Gui-Shuang Ying, PhD
1Scheie Eye Institute, University of Pennsylvania, Philadelphia
JAMA Ophthalmol. 2015;133(12):1482. doi:10.1001/jamaophthalmol.2015.3860.
December 1, 2015
Vatinee Y. Bunya, MD; Nicole M. Fuerst, MD; Mina Massaro-Giordano, MD
1Scheie Eye Institute, University of Pennsylvania, Philadelphia
JAMA Ophthalmol. 2015;133(12):1483. doi:10.1001/jamaophthalmol.2015.3897.
CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

163 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Jobs
brightcove.createExperiences();