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Comment & Response |

Accuracy, Reliability, and Consistency in the Collection of Tear Film Osmolarity Data—Reply

Vatinee Y. Bunya, MD1; Nicole M. Fuerst, MD1; Mina Massaro-Giordano, MD1
[+] Author Affiliations
1Scheie Eye Institute, University of Pennsylvania, Philadelphia
JAMA Ophthalmol. 2015;133(12):1483. doi:10.1001/jamaophthalmol.2015.3897.
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In Reply Aquavella discusses several possible factors (such as blinking effects and transitions from different environments) that have been studied in laboratory settings and may have contributed to the variability of measurements that we observed in our study.1 However, it is important to note that we conducted our study under conditions that can practically be controlled in a clinical setting and are similar to how the device is typically used in clinical practice. For example, all of our osmolarity testing was carried out in a climate-controlled room with closely monitored temperature and humidity. In addition, we were careful not to induce reflex tearing when obtaining measurements, and all readings were performed in accordance with the manufacturer’s instructions.


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December 1, 2015
Benjamin D. Sullivan, PhD; Jay S. Pepose, MD, PhD; Gary N. Foulks, MD
1TearLab Corporation, San Diego, California
2Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
3Department of Ophthalmology and Visual Sciences, University of Louisville, Kentucky
JAMA Ophthalmol. 2015;133(12):1481-1482. doi:10.1001/jamaophthalmol.2015.3854.
December 1, 2015
Laura E. Downie, BOptom, PhD, PGCertOcTher, DipMus(Prac), AMusA, FACO; Algis J. Vingrys, BSc(Optom), PhD, PGCertOcTher
1Department of Optometry and Vision Sciences, Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Melbourne, Australia
JAMA Ophthalmol. 2015;133(12):1480. doi:10.1001/jamaophthalmol.2015.3856.
December 1, 2015
James V. Aquavella, MD
1University of Rochester Flaum Eye Institute, Rochester, New York
JAMA Ophthalmol. 2015;133(12):1482-1483. doi:10.1001/jamaophthalmol.2015.3863.
December 1, 2015
Vatinee Y. Bunya, MD; Maxwell Pistilli, MEd, MS; Gui-Shuang Ying, PhD
1Scheie Eye Institute, University of Pennsylvania, Philadelphia
JAMA Ophthalmol. 2015;133(12):1482. doi:10.1001/jamaophthalmol.2015.3860.
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