0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Research Letter |

Proteomic Analysis of Macular Fluid Associated With Advanced Glaucomatous Excavation

Shriji Patel, MD1; Jeanie Ling, MD1; Stephen J. Kim, MD1; Kevin L. Schey, PhD1,2; Kristie Rose, PhD1,2; Rachel W. Kuchtey, MD, PhD1,3
[+] Author Affiliations
1Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee
2Department of Biochemistry, Vanderbilt University, Nashville, Tennessee
3Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee
JAMA Ophthalmol. 2016;134(1):108-110. doi:10.1001/jamaophthalmol.2015.4105.
Text Size: A A A
Published online

Extract

This case report describes the proteomic analysis of macular schisis fluid in a case of advanced glaucomatous cupping.

The association of maculopathy with advanced glaucomatous cupping is known, but controversy remains over the origin of fluid.13 Reports using enhanced depth imaging have demonstrated a track communicating from cavities posterior to the lamina cribrosa to the peripapillary retina, and these cavities presumably consist of cerebrospinal fluid (CSF).2,3

Figures in this Article

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption
Figure 1.
Color Fundus Photographs and Optical Coherence Tomography (OCT) of the Right and Left Eyes

A-D, Color fundus photographs of the right (A) and left (B) eyes, and OCT images of the right (C) and left (D) eyes. C, The right eye demonstrates glaucomatous excavation with a large macular schisis cavity on OCT. D, The left eye also shows glaucomatous changes but normal macular architecture.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Fluorescein Angiograms (FAs) and Enhanced Depth Imaging Optical Coherence Tomography (OCT) of the Right Eye

A and B, Early (A) and late (B) FAs show normal transit time as well as absence of vascular obstruction or vessel leakage. C, Enhanced depth imaging OCT through the optic nerve demonstrates a fluid cavity without visible defect in the lamina cribrosa or communication between the optic nerve and schisis pocket.

Graphic Jump Location

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

275 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();