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Central Retinal Vein Occlusion Noted 2 Days After Use of Phendimetrazine as an Appetite Suppressant

Ah Ran Cho, MD1; Young Hee Yoon, MD1
[+] Author Affiliations
1Department of Ophthalmology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea
JAMA Ophthalmol. 2016;134(4):463-464. doi:10.1001/jamaophthalmol.2015.5966.
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A woman in her 40s had sudden painless loss of vision in her left eye for 3 days. Fluorescein angiography revealed nonischemic central retinal vein occlusion of her left eye.

Phendimetrazine behaves as a sympathomimetic amine and is used as an appetite suppressant.1 We present a case of central retinal vein occlusion (CRVO) that developed after taking phendimetrazine for 2 days. The purpose of this case report is to draw attention to the potential for sight-threatening complications in patients receiving phendimetrazinen, although the event could have been coincidental to its use.

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Figure 1.
Patient’s Left Eye at First Visit

C, fluorescein angiography in the retinal arteriovenous phase. The arteriovenous transit time was delayed to about 24 seconds. D, Fluorescein angiography in the late phase.

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Figure 2.
Patient’s Left Eye 1 Month After Intravitreous Bevacizumab Injection

A, Retinal hemorrhages and axoplasmic swelling presumably from nerve fiber layer infarcts were resolved. B, Macular edema was reduced.

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