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Ophthalmic Images |

Optical Coherence Tomography of Cavitary Retinoblastoma Online Only

Timothy S. Fuller, MD1; Rizwan A. Alvi, MD1; Carol L. Shields, MD1
[+] Author Affiliations
1The Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania
JAMA Ophthalmol. 2016;134(5):e155355. doi:10.1001/jamaophthalmol.2015.5355.
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This case report describes a young boy with regressed retinoblastoma following intra-arterial chemotherapy.

Cavitary retinoblastoma is a unique form of retinoblastoma that demonstrates characteristic intralesional translucent cavities that are often more pronounced following tumor regression.14 There can be a single or multiple cavities, which are usually gray and spherical in configuration. Histopathologically, there is no endothelial or epithelial lining. The cavities are typically hypofluorescent on fluorescein angiography and echolucent on B-scan ultrasonography.2

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Figure.

A, Regressed cavitary retinoblastoma in a young boy following intra-arterial chemotherapy. The arrowheads indicate temporally located intratumoral cavitary spaces. B, This spectral-domain optical coherence tomography displays the fovea draped over solid retinoblastoma and temporally located intratumoral cavitary spaces, which spare the outer retina and are lined by thin inner retina.

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