We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Research Letter |

Variation in Ophthalmologist Use of Antivascular Endothelial Growth Factor Therapy Among Medicare Beneficiaries

Rachel V. Thakore, BS1; Paul B. Greenberg, MD1,2,3; Jess J. Behrens, MS4; Dustin D. French, PhD4,5,6
[+] Author Affiliations
1Division of Ophthalmology, Alpert Medical School, Brown University, Providence, Rhode Island
2Division of Ophthalmology, Rhode Island Hospital, Providence
3Section of Ophthalmology, Providence Veterans Affairs Medical Center, Providence, Rhode Island
4Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
5Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
6Veterans Affairs Health Services Research and Development Service, Chicago, Illinois
JAMA Ophthalmol. 2016;134(9):1071-1072. doi:10.1001/jamaophthalmol.2016.2051.
Text Size: A A A
Published online


This study compares the use of lower- vs higher-cost antivascular endothelial growth factor drugs prescribed for treatment of retinal vascular diseases in the Medicare population.

Antivascular endothelial growth factor (anti-VEGF) drugs used for ophthalmic conditions account for more than $6 billion in Part B Medicare costs.1 Recent research2,3 has shown that bevacizumab may be equally as effective as the more-expensive agents (aflibercept and ranibizumab) for some but not all retinal vascular diseases. Using provider-level billing data for Medicare beneficiaries, we analyzed geographic trends in anti-VEGF therapy to identify whether the use of lower-cost drugs increased among ophthalmologists from calendar years 2012 to 2013.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Antivascular Endothelial Growth Factor (Anti-VEGF) Drugs Used by the Greatest Percentage of Ophthalmologists per Hospital Referral Regions, 2012-2013

In some hospital referral regions, more than 1 anti-VEGF drug was used by the greatest percentage of ophthalmologists.

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles