We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
?ddi html font size="2">Clinicopathologic Reports, Case Reports, and Small Case Series |

Substance P, Insulinlike Growth Factor 1, and Surface Healing

Catherine H. Lee, MD; Amanda L. Whiteman, DVM; Christopher J. Murphy, DVM, PhD; Neal P. Barney, MD; Peter B. Taylor, MD; Ted W. Reid, PhD
Arch Ophthalmol. 2002;120(2):215-217. doi:.
Text Size: A A A
Published online


Impaired adhesion, migration, and/or mitosis can compromise corneal epithelial healing. Persistent epithelial defects can progress to ulceration, perforation, or endophthalmitis. Currently, our options are limited to methods that address the underlying cause of the epithelial defect. In addition to addressing exposure keratopathy, mechanical irritation to the eye, and systemic diseases, clinicians supplement the tear film, minimize the mechanical aspects of delayed wound healing, and use collagenolytic enzyme inhibitors. Specific therapy includes preservative-free artificial tears, pressure patching, bandage contact lens, and N-acetylcysteine. The more recent use of nerve growth factor,1 amniotic membrane transplantation,24 and scleral lens2 has been reported. Nonsurgical therapeutic options have limited effect, and surgical procedures such as lamellar or penetrating keratoplasty become necessary to preserve the anatomic integrity of the globe. Vision-threatening procedures (Gunderson flap, tarsorrhaphy, evisceration, or enucleation) may also become necessary.

Figures in this Article


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Figure 1.

Epithelial defect adjacent to region of graft override.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Intact epithelium after treatment with topical substance P and insulinlike growth factor 1. Fine superficial punctate staining and a whorl pattern lie in the previously defective area.

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

10 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.