The patient data were reviewed for demographic information, clinical findings and management, and histopathologic features. The data collected included the date of diagnosis, age at diagnosis (months), sex (male, female), race (African American, white, Hispanic, Asian), hereditary pattern (familial, sporadic), laterality (unilateral, bilateral), the eye involved (right, left), and prior treatment or intraocular surgery. The clinical information included intraocular pressure, presence of macroscopic anterior chamber seeding, and neovascularization of the iris. Reese-Ellsworth staging of retinoblastoma10 were noted for each patient. Histopathology reports were reviewed for the presence of specific features (Table 1). Details of systemic evaluation (computed tomographic scan, magnetic resonance imaging, bone marrow examination, cerebrospinal fluid cytology) were recorded. Details of postenucleation adjuvant therapy (chemotherapy, orbital external beam radiotherapy) were noted. In patients who received adjuvant chemotherapy, the drug regimen, duration, and systemic complications (as periodically assessed by a pediatric oncologist) were noted. In those who received adjuvant orbital external beam radiotherapy, the total dose and fractionation schedule were recorded. If adjuvant therapy was not administered, the reason governing the decision was elicited. Information regarding the outcome included occurrence of metastasis, date of detection of metastasis, interval between enucleation and detection of metastasis (months), and the site of metastasis. The final patient outcome (alive without metastasis, alive with metastasis, alive with second malignant neoplasm, dead with metastasis, dead with second malignant neoplasm, or dead because of other causes), the date of last follow-up, and the duration of follow-up were noted.