All tumors were treated with 125I plaque radiotherapy using standard Collaborative Ocular Melanoma Study–style plaques prescribed to deliver 8500 rad (85 Gy) to the tumor apex in 4 to 5 days. Postoperative follow-up visits were typically performed at 3, 6, 9, 12, 16, 20, 24, 30, and 36 months, and at least annually thereafter. Some patients with atypical treatment response were followed up more frequently. Documentation at each follow-up visit included visual acuity, tumor basal diameter, tumor thickness by A-scan ultrasonography, size of the ERD, additional treatments (eg, laser therapy, thermotherapy, and enucleation), and reason for treatment (eg, unresponsiveness or local recurrence). Tumor responsiveness was defined as resolution of the ERD and a demonstrable decrease in tumor thickness (usually >10%, depending on the length of follow-up). Local recurrence was defined as regrowth of a previously responsive tumor by at least 1 mm in either the horizontal or vertical dimension, as measured by fundus photographs or A-scan ultrasonography, respectively.