Malignant fibrous histiocytoma is the most frequent soft tissue sarcoma of the elderly,1 involving predominantly the extremities and retroperitoneum,1,11 but also occurring in other sites including the ocular adnexa.2,5- 10 The histological differential diagnosis of MFH includes pleomorphic carcinoma, malignant melanoma, and other sarcomas.1 The absence of dysplastic changes of the surface epithelium, lack of connection of the latter with the neoplasm, absence of immunoreactivity for epithelial markers, and ultrastructural findings are against a diagnosis of carcinoma. Malignant melanoma, rhabdomyosarcoma, leiomyosarcoma, and liposarcoma were excluded on the basis of immunohistochemical and ultrastructural findings. Cellular elements having the characteristics of fibroblasts, myofibroblasts, and histiocytes can be found, by electron microscopy, in cases of MFH1 as well as in cases of benign fibrous histiocytoma.4 The immunohistochemical profile of the neoplastic cells was also in agreement with a fibrohistiocytic tumor composed predominantly of myofibroblasts (positive reactivity to vimentin and smooth muscle actin and negative reactivity to desmin) and histiocytes (positive reactivity to vimentin, CD68 [KP-1], and α1-antichymotrypsin). Binder and colleagues12 demonstrated the usefulness of the monoclonal antibody CD68 (KP-1) in cases of MFH. Sensitivity of staining for CD68 (KP-1) was 72% in cases of MFH and 0% for other sarcomas.