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Clinical Sciences |

A New Method for Measuring Progression in Patients With Ocular CicatricialPemphigoid FREE

J. James Rowsey, MD; Yolanda Macias-Rodriguez, MD; Chris Cukrowski, DO
[+] Author Affiliations

From the Department of Cornea and External Diseases,St Luke's Cataract and Laser Institute, Tarpon Springs, Fla (Drs Rowsey and Cukrowski); and the Department of Ophthalmology, Instituto Tecnológico y deEstudios Superiores de Monterrey, Monterrey, N. L. Mexico(Dr Macias-Rodriguez). The authors have no relevant financial interest inthis article.


Arch Ophthalmol. 2004;122(2):179-184. doi:10.1001/archopht.122.2.179.
Text Size: A A A
Published online

Objectives  To describe a method to measure the progression of ocular cicatricialpemphigoid and to compare its facility with traditional methods used to measurethe progression of the disease.

Methods  The proposed method consists of measuring (in millimeters) the totalrelative inferior conjunctival surface available in 3 gaze positions. Thismethod was used to monitor 7 eyes of 4 patients with ocular cicatricial pemphigoidover 2 years. The changes in the conjunctival measurements from baseline werecompared with the changes documented by traditional methods.

Results  During the study, 2 eyes remained stable (changes, <3 mm), 2 hada decrease of 10 mm or more, and 3 had a change in measurements between 4and 9 mm. With the proposed method, we demonstrated the detection of moresubtle changes in the conjunctiva of all patients. Patients who had changesbetween 4 and 9 mm easily underwent staging by the traditional systems whenthe new technique was used as a reference.

Conclusion  The proposed method offers an objective variable that can be used inconsecutive visits to detect subtle progression or disease control in patientswith ocular cicatricial pemphigoid.

Figures in this Article

Ocular cicatricial pemphigoid (OCP) is an acquired autoimmune mucousmembrane pemphigoid, type II hypersensitivity reaction, in which the antigen-antibody-complementinteraction occurs at the level of the conjunctival epithelial basement membranezone.13 Bullouspemphigoid 180, laminin 5, and β4 integrin are the purportedantigens located in the transmembrane hemidesmosomal area in the lamina lucida.311

Clinically, OCP is a bilateral disease that is characterized by acuteinflammation of the conjunctiva, with redness, blisters, and ulceration ofthe conjunctiva. Chronic inflammation is associated with subepithelial scarringthat leads to fornix shortening.1214 Morerecently, the combined influences of connective tissue growth factor and transforminggrowth factor β1 in the cascade of scarring have been demonstrated.15 This scarring induces eyelid distortion, keratinizationof the ocular surface, and eventual ocular fixation causing blindness.1316 Theprogression of pemphigoid may be subtle and variable, despite aggressive immunosuppressivetherapy. Minimal changes in the conjunctiva, especially conjunctival shrinkage,fornix shortening, and progressive symblepharon, may elude documentation.Algorithms may not categorize the progressive loss of the conjunctival surfaceand may miss valuable intervention time.

The proved methods for monitoring changes in patients with OCP are thestaging systems described by Tauber and coworkers,17 Foster,18 and Mondino and Brown.19 Thesemethods are invaluable for staging the disease, but do not provide sufficientdiscriminate information for detecting subtle changes in the conjunctivalfornix. The disease can progress undocumented within the same stage in eithersystem. We have developed a method to document nuances of progression thathas been helpful for providing earlier intervention whenever the disease becomesmore active. This article describes this method and compares its facilitywith traditional methods used to measure the progression of the disease.

A clinical method to measure the amount of conjunctival shrinkage wasdesigned to detect progressive cicatricial changes in the conjunctiva of patientswith OCP. It was used in the regular appointments of 4 patients for 2 years.Each patient was informed of the measurement technique being used and thepurpose of the measurement. No observer was masked. This method was comparedwith 2 of the standard methods of staging the disease, described by Tauberet al17 and Mondino and Brown.19 Thecomparison was made to see which methods could document minute changes inthe conjunctiva of the patients with OCP between appointments.

PATIENTS

We made the comparison in 4 patients with confirmed OCP (7 eyes). The4 patients were women, ranging in age from 69 to 77 years. Table 1 shows the clinical summaries of the patients.

Table Graphic Jump LocationTable 1. Clinical Summaries of the Patients*

Measurements and staging were performed at each appointment of these4 patients, and the changes between each appointment were documented.

NEW METHOD TO MEASURE THE CONJUNCTIVA

The new method consists of measuring (in millimeters) the distance betweenthe lower limbus and the posterior edge of the retracted lower eyelid marginin 3 different gaze positions: looking up, looking up to the right, and lookingup to the left. These gaze positions place the examined conjunctiva on stretchat the 5-, 6-, and 7-o'clock positions. Measurements are taken in millimetersof the stretched conjunctiva. The subconjunctival cicatrix allows eyelid tractionto pull the eye inferiorly. As the patient looks up, the eyelid is pulleddown until the globe first moves due to the traction on the eyelid. A measurementis taken along each direction of gaze (Figure1, A-D).

Place holder to copy figure label and caption

A, Conjunctival stretching measurements in a patient with cicatricialpemphigoid. The measures (in millimeters) are taken in 3 different gaze positions.The 5-o'clock position is demonstrated. B-D, Method to measure the conjunctiva.The measures (in millimeters) are taken from the lower limbus to the posterioredge of the retracted lower eyelid in 3 different gaze positions: 5-o'clockposition (B), 6-o'clock position (C), and 7-o'clock position (D). The sumof the 3 measurements (B, 13 mm; C, 10 mm; and D, 13 mm) represents the finalvalue (36 mm). E, Schematic diagram used in the medical records to describethe measurements in 3 gaze positions. This diagram summarizes the measurementsin parts B through D.

Graphic Jump Location

The result of the sum of the 3 measurements is noted in the medicalrecord at each appointment beside a simple line diagram (Figure 1, E). The normal conjunctiva measurement is approximately15 mm in each area of the inspection (sum, 45 mm). This is the total "available"conjunctiva.

We compared the apparent conjunctival shrinkage in millimeters withthe staging system of Mondino and Brown.19

THE STAGING SYSTEM OF MONDINO AND BROWN

This method is based on the percentage of conjunctival shrinkage. StageI of cicatricial pemphigoid shows 25% or less shrinkage of the conjunctivalfornices. Stage II of cicatricial pemphigoid shows 25% to 50% conjunctivalshrinkage. Stage III of cicatricial pemphigoid shows conjunctival shrinkageof about 75%. The inferior fornix is nearly obliterated; the shallow superiorfornix is still present. Stage IV or the end stage of cicatricial pemphigoidshows obliteration of the conjunctival fornices.

THE STAGING SYSTEM OF TAUBER ET AL

This method describes conjunctival destruction and the presence of symblepharon:stage I, chronic conjunctivitis and subepithelial fibrosis; stage II, fornixforeshortening by any degree; stage III, symblepharon by any degree; and stageIV, ankyloblepharon and a frozen globe.

To describe degrees within stages II and III, a indicates 0% to 25%;b, 25% to 50%; c, 50% to 75%; and d, 75% to 100%.

For stage II, a through d describe percentage loss of inferior fornixdepth. For stage III, a through d describe percentage of horizontal involvementby symblephara, and describe the number of symblephara counted in each patient.

The results of these 4 patients are congruent with the extant stagingsystems of Mondino and Brown19 and Tauber etal.17

These methods were compared at each appointment. We compared date ofservice, conjunctival measurement, stages of Tauber et al17 andMondino and Brown,19 time between visits, changesfrom baseline, and interventions.

We calculated the stage of Tauber et al17 andMondino and Brown,19 based on the differencein millimeters measured at the slitlamp examination. If 100% of the availableconjunctiva measures 45 mm in a healthy eye, then 32 mm represents 25% ofconjunctival loss; 22 mm, 50% loss; and 11 mm, 75% loss.

In patient 1, minimal shortening was noted at the first visit in eacheye. After surgical procedures on the eyelid in both eyes, the right eye showeda shortening of 12 mm in 6 months, and the left eye fornix was reduced afterthe surgery from 42 to 30 mm (loss of 12 mm). These changes represent progressionfrom stage IIaIIIa(1) to IIbIIIa(1) by Tauber et al17 orfrom stage I to II by Mondino and Brown19 forthe right eye, and from stage IIa to IIb by Tauber et al or from stage I toII by Mondino and Brown for the left eye. The treatment with methotrexatewas increased to 20 mg/wk, and then reduced to 15 mg/wk (Table 2).

Table Graphic Jump LocationTable 2. Measurements and Changes During the Study in Patient 117,19

In patient 2, the right eye demonstrated no progression in 9 months,but the left eye demonstrated a minute progression of 2 mm. This 2 mm is withinthe variation of the measurement technique. By measuring the staging change,the left eye demonstrated progression from stage IIa to IIb (Tauber et al17) and from stage I to II (Mondino and Brown19). The eye remained stable throughout the follow-up(Table 3).

Table Graphic Jump LocationTable 3. Measurements and Changes During the Study in Patients 2 Through417,19

In patient 3, the right eye progressed from 36 to 32 mm. When the patientwas treated with methotrexate, 25 mg/wk, only 4 mm of conjunctival surfacewas subsequently lost in the follow-up period. This corresponds to a changefrom stage IIaIIIb(1) to IIbIIIb(1) (Tauber et al17)and from stage I to II (Mondino and Brown19)(Table 3).

The left eye progressed from 34 to 30 mm in 17 months, or a decreasefrom stage IIaIIIb(1) to IIbIIIb(1) (Tauber et al17)and from stage I to II (Mondino and Brown19).Immunosuppressive initial treatment was methotrexate, 25 mg/wk; then, cyclosporine,100 mg/d, was added (Table 3).

Patient 4 demonstrated 30 mm of conjunctiva at the first visit, andafter 6 months of treatment with prednisone, in doses from 30 to 40 mg/d,and methotrexate, 10 mg/wk, had an expansion of the conjunctiva to 36 mm.This relaxation of the conjunctiva with treatment is consistent with a regressionof scarring from stage IIbIIIa(1) to IIaIIIa(1) by Tauber et al17 andfrom stage II to I by Mondino and Brown19 (Table 3).

Two major therapeutic frustrations confront the clinician treating OCP:the early diagnosis and the determination of progression when the diagnosisis established.1622 Thispotentially blinding disease may be missed in the early stages because ofnonspecific patient complaints of redness and irritation and the subtle conjunctivalchanges of subepithelial fibrosis.12,23 Thesepatient complaints may be treated as different common conjunctival entitiesfor years before the true nature of the problem surfaces with the earliestsigns of conjunctival shrinkage.20,23

The most common mimics of pemphigoid are old acute or current chronicconjunctivitis, chemical injuries, drug toxicities, Sjögren syndrome,and sarcoid.13,24

A history of severe prior conjunctivitis, corneal scars of old adenovirus,cultures of the conjunctiva, a history of fluids splashed in the eye, andprior drug use, especially for glaucoma, may all help in delineating the causeof conjunctival scarring.531 Treatmentmodalities, such as oral dapsone,32 topicalor systemic corticosteroids,15 eliminationof toxic drugs, immunosuppressive agents,3336 orconjunctival reconstruction,37 all hinge onthe perspicacity of the clinician in determining progression.

Acute disease activity may lead to rapid progression, whereas slow progressionmay be associated with minimal conjunctival erythema.16,33 Mondinoand Brown33 noted that 9 (50%) of 18 patientswith stage I disease demonstrated progression during a 22-month follow-upperiod. Unfortunately, the more severe the disease, the greater the tendencyto progression. Patients with stage II disease demonstrated a 75% progressionrate, and those with stage III disease, a 78% progression rate. This studysuggests that the later stages of the disease may progress without carefulmonitoring and intervention. The advanced staging system of Tauber et al17 defines more readily the presence of symblepharain addition to fornix depth loss.

We propose a method of measurement that one of us (J.J.R.) has usedfor the past 6 years to determine if disease progression or stability canbe ascertained in the face of a reasonable therapeutic intervention. We havenoted that the normal measurement of the inferior conjunctiva is approximately15 mm in each observed area, for a cumulative total of 45 mm. Patients arefirst diagnosed as having the disease, however, after conjunctival shrinkagehas already occurred. No patient demonstrated a full 45 mm of residual conjunctivawhen diagnosed as having pemphigoid.

The proposed technique is useful for comparing the same patient dataagainst previous examination results. A cumulative measurement decrease ofmore than 3 mm is reasonably consistent with disease progression. The instructionto retract the lower eyelid while the patient is in an upward gaze providescomparable results between observers. Intraobserver and interobserver variationshave not been addressed in this analysis. Measurement errors between examinationsmay occur if a different retraction pressure is applied to the lower eyelid.The end point of first globe movement on eyelid retraction is the best standardizedtechnique for providing consistent measurements. It is reasonably easy tostage the disease by the published methods, once the progression (in millimeters)is documented. The millimeter measurement is more readily compared than evena serial photographic comparison. It is easy to document a linear 45-mm cicatrizationto 33 mm, all in stage IIa of the disease (0%-25% loss). Similarly, cumulativeloss of the conjunctival total from 32 to 22 mm is more readily appreciatedthan determining if any progression has occurred within stage IIb (25%-50%loss). We have documented the independent addition of symblephara at eachvisit on the medical record, but have noted that this progressive shorteningis normally documented as an extension of the subepithelial fibrosis alreadybeing measured. Horizontal shortening of the eyelid seems to be reflectedin the simultaneous vertical conjunctival fibrosis being measured. We wereintrigued that some disease regression appeared with heavy treatment, as inpatient 4. Previous observers have not suggested disease regression with expansionof the conjunctival surface with aggressive intervention. We are unable todetermine if this is truly relaxation and expansion of the conjunctiva ordecreased orbicularis spasm with eyelid retraction when the disease remits.By using this technique, we were able to classify our patients more readilythan by the system of either Tauber et al17 orMondino and Brown,19 and were able to ascertainsubtle progression between stages. Validation of the technique with a largerseries of patients with OCP is warranted. We submit this proposed simplifiedtechnique for others to consider in these difficult therapeutic decisions.

In conclusion, a new method of measuring conjunctival progressive fibrosisin patients with OCP is proposed. Four patients demonstrated changes in conjunctivalcicatrization during a 2-year period. Use of this method demonstrates subtleprogression of pemphigoid.

Corresponding author and reprints: J. James Rowsey, MD, Departmentof Cornea and External Diseases, St Luke's Cataract and Laser Institute, 43309US Hwy 19 N, PO Box 5000, Tarpon Springs, FL 34688-5000 (e-mail: jrowsey@tampabay.rr.com).

Submitted for publication March 21, 2003; final revision received October8, 2003; accepted October 14, 2003.

We thank Mark Erickson, Department of Photography, St Luke's Cataractand Laser Institute (www.jirehdesign.com), for providing the illustrations.

Giuri  S Ocular cicatricial pemphigoid [in Romanian]. Oftalmologia. 1999;4713- 21
PubMed
Zillikens  D Acquired skin disease of hemidesmosomes. J Dermatol Sci. 1999;20134- 154
PubMed Link to Article
Chan  LS Human skin basement membrane in health and in autoimmune diseases. Front Biosci. 1997;2D343- D352
PubMed
Kumari  SBhol  KCSimmons  RK  et al.  Identification of ocular cicatricial pemphigoid antibody binding site(s)in human β4 integrin. Invest Ophthalmol Vis Sci. 2001;42379- 385
PubMed
Egan  CAYancey  KB The clinical and immunopathological manifestations of anti-epiligrincicatricial pemphigoid, a recently defined subepithelial autoimmune blisteringdisease. Eur J Dermatol. 2000;10585- 589
PubMed
Leverkus  MSchmidt  ELazarova  ZBrocker  EBYancey  KBZillikens  D Antiepiligrin cicatricial pemphigoid: an underdiagnosed entity withinthe spectrum of scarring autoimmune subepidermal bullous diseases? Arch Dermatol. 1999;1351091- 1098
PubMed Link to Article
Zillikens  D BP180 as the common autoantigen in blistering diseases with differentclinical phenotypes. Keio J Med. 2002;5121- 28
PubMed Link to Article
Kromminga  ASitaru  CMeyer  J  et al.  Cicatricial pemphigoid differs from bullous pemphigoid and pemphigoidgestationis regarding the fine specificity of autoantibodies to the BP180NC16A domain. J Dermatol Sci. 2002;2868- 75
PubMed Link to Article
Kirtschig  G Autoantigens of cicatricial pemphigoid and their pathogenetic significance[in German]. Hautarzt. 1998;49818- 825
PubMed Link to Article
Lazarova  ZHsu  RYee  CYancey  KB Antiepiligrin cicatricial pemphigoid represents an autoimmune responseto subunits present in laminin 5 (α3β2). Br J Dermatol. 1998;139791- 797
PubMed Link to Article
Fujimoto  WToi  YOkazaki  FLazarova  ZYancey  KBArata  J Anti-epiligrin cicatricial pemphigoid with IgG autoantibodies to thebeta and gamma subunits of laminin 5. J Am Acad Dermatol. 1999;40637- 639
PubMed Link to Article
Mondino  BJManthey  R Dermatological diseases and the peripheral cornea. Int Ophthalmol Clin. 1986;26121- 136
PubMed Link to Article
Mondino  BJBartly  JHovanesian  JPleyer  U Bullous diseases of the skin and mucous membranes. Duaneeds.Clinical Ophthalmology [bookon CD-ROM].4 Philadelphia, Pa Lippincott Williams & Wilkins2001;chap12.
Mondino  BJ Cicatricial pemphigoid and erythema multiforme. Ophthalmology. 1990;97939- 952
PubMed Link to Article
Razzaque  MSFoster  CSAhmed  AR Role of connective tissue growth factor in the pathogenesis of conjunctivalscarring in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci. 2003;441998- 2003
PubMed Link to Article
Mondino  BJBrown  SILempert  SJenkins  MS The acute manifestations of ocular cicatricial pemphigoid: diagnosisand treatment. Ophthalmology. 1979;86543- 555
PubMed Link to Article
Tauber  JJabbur  NFoster  CS Improved detection of disease progression in ocular cicatricial pemphigoid. Cornea. 1992;11446- 451
PubMed Link to Article
Foster  CS Cicatricial pemphigoid. Trans Am Ophthalmol Soc. 1986;84527- 663
PubMed
Mondino  BJBrown  SI Ocular cicatricial pemphigoid. Ophthalmology. 1981;8895- 100
PubMed Link to Article
Holsclaw  DS Ocular cicatricial pemphigoid. Int Ophthalmol Clin. 1998;3889- 106
PubMed Link to Article
Messmer  EMHintschich  CRPartscht  KMesser  GKampik  A Ocular cicatricial pemphigoid: retrospective analysis of risk factorsand complications [in German]. Ophthalmologe. 2000;97113- 120
PubMed Link to Article
Elder  MJBernauer  WLeonard  JDart  JK Progression of disease in ocular cicatricial pemphigoid. Br J Ophthalmol. 1996;80292- 296
PubMed Link to Article
Baier  GZillikens  D Cicatricial pemphigoid—an important differential diagnosis ininflammatory mucous membrane changes [in German]. Laryngorhinootologie. 1999;78632- 637
PubMed Link to Article
Flach  A Symblepharon in sarcoidosis. Am J Ophthalmol. 1978;85210- 214
PubMed
Darougar  SQuinlan  MPGibson  JAJones  BR Epidemic keratoconjunctivitis and chronic papillary conjunctivitisin London due to adenovirus type 19. Br J Ophthalmol. 1977;6176- 85
PubMed Link to Article
Bialy-Golan  ABrenner  S Penicillamine-induced bullous dermatoses. J Am Acad Dermatol. 1996;35 (pt 1) 732- 742
PubMed Link to Article
Lass  JHThoft  RADohlman  CH Idoxuridine-induced conjunctival cicatrization. Arch Ophthalmol. 1983;101747- 750
PubMed Link to Article
Patten  JTCavanagh  HDAllansmith  MR Induced ocular pseudopemphigoid. Am J Ophthalmol. 1976;82272- 276
PubMed
Kubo  MSakuraba  TArai  YNakazawa  M A case of suspected drug-induced ocular pemphigoid [in Japanese]. Nippon Ganka Gakkai Zasshi. 2001;105189- 192
PubMed
Pouliquen  YPatey  AFoster  CSGoichot  LSavoldelli  M Drug-induced cicatricial pemphigoid affecting the conjunctiva: lightand electron microscopic features. Ophthalmology. 1986;93775- 783
PubMed Link to Article
Fiore  PMJacobs  IHGoldberg  DB Drug-induced pemphigoid: a spectrum of diseases. Arch Ophthalmol. 1987;1051660- 1663
PubMed Link to Article
Rogers 3rd  RSSeehafer  JRPerry  HO Treatment of cicatricial (benign mucous membrane) pemphigoid with dapsone. J Am Acad Dermatol. 1982;6215- 223
PubMed Link to Article
Mondino  BJBrown  SI Immunosuppressive therapy in ocular cicatricial pemphigoid. Am J Ophthalmol. 1983;96453- 459
PubMed
Tauber  JSainz de la Maza  MFoster  CS Systemic chemotherapy for ocular cicatricial pemphigoid. Cornea. 1991;10185- 195
PubMed Link to Article
Elder  MJLightman  SDart  JK Role of cyclophosphamide and high dose steroid in ocular cicatricialpemphigoid. Br J Ophthalmol. 1995;79264- 266
PubMed Link to Article
Bohn  JJonsson  SHolst  R Successful treatment of recalcitrant cicatricial pemphigoid with acombination of plasma exchange and cyclophosphamide. Br J Dermatol. 1999;141536- 540
PubMed Link to Article
Trigui  AKammoun  BGhodhbane  MFourati  MMseddi  MChaabouni  M Penetrating keratoplasty in ocular cicatricial pemphigoid [in French]. J Fr Ophtalmol. 2002;2548- 51
PubMed

Figures

Place holder to copy figure label and caption

A, Conjunctival stretching measurements in a patient with cicatricialpemphigoid. The measures (in millimeters) are taken in 3 different gaze positions.The 5-o'clock position is demonstrated. B-D, Method to measure the conjunctiva.The measures (in millimeters) are taken from the lower limbus to the posterioredge of the retracted lower eyelid in 3 different gaze positions: 5-o'clockposition (B), 6-o'clock position (C), and 7-o'clock position (D). The sumof the 3 measurements (B, 13 mm; C, 10 mm; and D, 13 mm) represents the finalvalue (36 mm). E, Schematic diagram used in the medical records to describethe measurements in 3 gaze positions. This diagram summarizes the measurementsin parts B through D.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 1. Clinical Summaries of the Patients*
Table Graphic Jump LocationTable 2. Measurements and Changes During the Study in Patient 117,19
Table Graphic Jump LocationTable 3. Measurements and Changes During the Study in Patients 2 Through417,19

References

Giuri  S Ocular cicatricial pemphigoid [in Romanian]. Oftalmologia. 1999;4713- 21
PubMed
Zillikens  D Acquired skin disease of hemidesmosomes. J Dermatol Sci. 1999;20134- 154
PubMed Link to Article
Chan  LS Human skin basement membrane in health and in autoimmune diseases. Front Biosci. 1997;2D343- D352
PubMed
Kumari  SBhol  KCSimmons  RK  et al.  Identification of ocular cicatricial pemphigoid antibody binding site(s)in human β4 integrin. Invest Ophthalmol Vis Sci. 2001;42379- 385
PubMed
Egan  CAYancey  KB The clinical and immunopathological manifestations of anti-epiligrincicatricial pemphigoid, a recently defined subepithelial autoimmune blisteringdisease. Eur J Dermatol. 2000;10585- 589
PubMed
Leverkus  MSchmidt  ELazarova  ZBrocker  EBYancey  KBZillikens  D Antiepiligrin cicatricial pemphigoid: an underdiagnosed entity withinthe spectrum of scarring autoimmune subepidermal bullous diseases? Arch Dermatol. 1999;1351091- 1098
PubMed Link to Article
Zillikens  D BP180 as the common autoantigen in blistering diseases with differentclinical phenotypes. Keio J Med. 2002;5121- 28
PubMed Link to Article
Kromminga  ASitaru  CMeyer  J  et al.  Cicatricial pemphigoid differs from bullous pemphigoid and pemphigoidgestationis regarding the fine specificity of autoantibodies to the BP180NC16A domain. J Dermatol Sci. 2002;2868- 75
PubMed Link to Article
Kirtschig  G Autoantigens of cicatricial pemphigoid and their pathogenetic significance[in German]. Hautarzt. 1998;49818- 825
PubMed Link to Article
Lazarova  ZHsu  RYee  CYancey  KB Antiepiligrin cicatricial pemphigoid represents an autoimmune responseto subunits present in laminin 5 (α3β2). Br J Dermatol. 1998;139791- 797
PubMed Link to Article
Fujimoto  WToi  YOkazaki  FLazarova  ZYancey  KBArata  J Anti-epiligrin cicatricial pemphigoid with IgG autoantibodies to thebeta and gamma subunits of laminin 5. J Am Acad Dermatol. 1999;40637- 639
PubMed Link to Article
Mondino  BJManthey  R Dermatological diseases and the peripheral cornea. Int Ophthalmol Clin. 1986;26121- 136
PubMed Link to Article
Mondino  BJBartly  JHovanesian  JPleyer  U Bullous diseases of the skin and mucous membranes. Duaneeds.Clinical Ophthalmology [bookon CD-ROM].4 Philadelphia, Pa Lippincott Williams & Wilkins2001;chap12.
Mondino  BJ Cicatricial pemphigoid and erythema multiforme. Ophthalmology. 1990;97939- 952
PubMed Link to Article
Razzaque  MSFoster  CSAhmed  AR Role of connective tissue growth factor in the pathogenesis of conjunctivalscarring in ocular cicatricial pemphigoid. Invest Ophthalmol Vis Sci. 2003;441998- 2003
PubMed Link to Article
Mondino  BJBrown  SILempert  SJenkins  MS The acute manifestations of ocular cicatricial pemphigoid: diagnosisand treatment. Ophthalmology. 1979;86543- 555
PubMed Link to Article
Tauber  JJabbur  NFoster  CS Improved detection of disease progression in ocular cicatricial pemphigoid. Cornea. 1992;11446- 451
PubMed Link to Article
Foster  CS Cicatricial pemphigoid. Trans Am Ophthalmol Soc. 1986;84527- 663
PubMed
Mondino  BJBrown  SI Ocular cicatricial pemphigoid. Ophthalmology. 1981;8895- 100
PubMed Link to Article
Holsclaw  DS Ocular cicatricial pemphigoid. Int Ophthalmol Clin. 1998;3889- 106
PubMed Link to Article
Messmer  EMHintschich  CRPartscht  KMesser  GKampik  A Ocular cicatricial pemphigoid: retrospective analysis of risk factorsand complications [in German]. Ophthalmologe. 2000;97113- 120
PubMed Link to Article
Elder  MJBernauer  WLeonard  JDart  JK Progression of disease in ocular cicatricial pemphigoid. Br J Ophthalmol. 1996;80292- 296
PubMed Link to Article
Baier  GZillikens  D Cicatricial pemphigoid—an important differential diagnosis ininflammatory mucous membrane changes [in German]. Laryngorhinootologie. 1999;78632- 637
PubMed Link to Article
Flach  A Symblepharon in sarcoidosis. Am J Ophthalmol. 1978;85210- 214
PubMed
Darougar  SQuinlan  MPGibson  JAJones  BR Epidemic keratoconjunctivitis and chronic papillary conjunctivitisin London due to adenovirus type 19. Br J Ophthalmol. 1977;6176- 85
PubMed Link to Article
Bialy-Golan  ABrenner  S Penicillamine-induced bullous dermatoses. J Am Acad Dermatol. 1996;35 (pt 1) 732- 742
PubMed Link to Article
Lass  JHThoft  RADohlman  CH Idoxuridine-induced conjunctival cicatrization. Arch Ophthalmol. 1983;101747- 750
PubMed Link to Article
Patten  JTCavanagh  HDAllansmith  MR Induced ocular pseudopemphigoid. Am J Ophthalmol. 1976;82272- 276
PubMed
Kubo  MSakuraba  TArai  YNakazawa  M A case of suspected drug-induced ocular pemphigoid [in Japanese]. Nippon Ganka Gakkai Zasshi. 2001;105189- 192
PubMed
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