To study the visual and angiographic outcome of eyes with neovascularage-related macular degeneration associated with pigment epithelium detachment(PED) treated by photodynamic therapy.
Review of the medical charts and the fluorescein and indocyanine greenangiograms of all consecutive patients with age-related macular degenerationassociated with choroidal neovascularization and serous PED of at least 1disc diameter, who received photodynamic therapy from January 1, 2000, toAugust 31, 2002.
Thirty patients (34 eyes) met the study criteria. Each underwent 1 to8 treatments (mean, 4); duration of follow-up was 12 to 36 months (mean, 19months). Nineteen eyes (56%) lost 3 or more Snellen lines of visual acuity,7 eyes (21%) lost 1 or 2 lines, 6 eyes (18%) maintained their initial acuity,and 2 eyes (6%) gained 1 or 2 lines. Subretinal hemorrhage occurred in 5 eyesand retinal pigment epithelium tears in 4 eyes. In 4 eyes, visual acuity decreasedto counting fingers, hand motions, or light perception.
Although 44% of the 34 eyes with age-related macular degeneration andPED lost fewer than 3 Snellen lines in acuity, severe visual loss to countingfingers or less occurred in 4 eyes, 3 of them with choroidal neovascularizationinside the PED. Further studies and treatment modalities are required to improveprognosis of neovascular age-related macular degeneration with serous PED.