There are some data to support a beneficial effect of high-dose antioxidantsupplements in delaying or preventing cataracts, but overall the body of evidenceis weak. In 2 large clinical trials,30,31 high-doseantioxidants did not delay cataract over approximately 6 years. However, ina smaller trial (158 persons who completed the 3-year study), antioxidantsupplements did delay early lens opacification.32 Inthe latter trial, blood levels of antioxidants were higher in the supplementedgroup, and lower in the control groups, than in the AREDS,30 whichmight explain the differing results. However, confirmation of this smallertrial is important to rule out the possibility that chance or some featuresof the study design, implementation, or population explain the positive resultsthat differ with the results of other clinical trials. Also, while this trialand results of several observational studies have reported lower occurrenceof lens opacities among people taking antioxidant supplements, they did notdemonstrate benefits beyond those that would be possible from general multivitamins.