To describe parental perspectives on health status and health-relatedquality of life (HRQL) at age 10 years in children with birth weights lessthan 1251 g who participated in the multicenter Cryotherapy for Retinopathyof Prematurity (CRYO-ROP) study.
In 244 participants in the randomized CRYO-ROP trial and 102 CRYO-ROPparticipants who did not develop ROP, the Health Utilities Index (HUI) systemwas used to characterize health status for the following 8 attributes: vision,hearing, speech, ambulation, dexterity, emotion, cognition, and pain. Usinga utility formula, HRQL was determined for each child on a scale from 0.0(dead) to 1.00 (perfect health).
The proportion of the ROP-randomized group with limitations in 4 attributesor more was 20.6% compared with 2.0% for the no-ROP group. Within the ROP-randomizedgroup, the proportion of “sighted” children with limitations in4 attributes or more was 6.4% vs 46.5% in the “blind/low vision”group. The median HRQL score for the ROP-randomized children was lower thanfor the no-ROP children (0.72 vs 0.97, P<.001);the median HRQL score for the sighted-randomized children was 0.87 vs 0.27for the blind/low vision children (P<.001).
Threshold ROP was associated with functional limitations in health attributesand reduction in HRQL scores at age 10 years. Furthermore, among childrenwho developed threshold ROP, a greater reduction in HRQL scores was foundamong children with a poor visual outcome compared with those with bettersight.