To report in vivo corneal confocal microscopic findings of patientswith central cloudy dystrophy of François.
Two unrelated patients, a 78-year-old man and a 75-year-old woman, withcentral cloudy dystrophy of François were examined using routine slitlampbiomicroscopy and confocal microscopy.
In both cases, slitlamp biomicroscopy showed bilateral polygonal opacitiesseparated by clear spaces. The corneal opacities were most prominent centrallyand were located in the deeper stromal layer immediately anterior to the Descemetmembrane. By confocal microscopy, normal superficial and basal epitheliallayers, midstromal layers, and endothelial layers were noted in both cases.However, small highly refractile granules and deposits were observed in theanterior stromal layer in both cases. Also, multiple dark striae among theextracellular matrix with increased intensities were observed in the posteriorstroma adjacent to the corneal endothelial layer in both cases.
Abnormal stromal deposits and multiple dark striae were observed incentral cloudy dystrophy of François using in vivo corneal confocalmicroscopy. Use of confocal microscopy to investigate these abnormal stromalopacities may be helpful in differentiating various corneal stromal pathologicfeatures.