The retinal depression sign was first described in sickle cell retinopathy in 1978 by Goldbaum.1 It represents an area of focal retinal infarction that may occur not only in the retinopathy of sickling hemoglobinopathies, but also in other microvascular disorders such as diabetic2 and hypertensive3 retinopathies.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
figure 1. Fundus photograph confirms the presence of the retinal depression sign superotemporal to the fovea (arrowheads). Note the dark area with a central light streak within the light reflecting from the internal limiting lamina. The areas demarcated by the square and circle outline the areas mapped using the retinal thickness analyzer and optical coherence tomography, respectively.
figure 2. A, Retinal thickness map generated by the retinal thickness analyzer shows diminished retinal thickness superotemporal to the fovea, corresponding spatially to the lesion observed on the fundus photograph (figure 1). B, Deviation probability map of the same eye using the retinal thickness analyzer, derived by comparison with the normative database, shows a well-delineated region of lower-than-normal thickness in the region occupied by the lesion. f indicates the fovea.
figure 3. A, A 6-mm optical coherence tomographic horizontal scan was obtained over the retinal area having the depression sign. The retinal depression was clearly visible (arrowhead). B, A 6-mm optical coherence tomographic scan through the center of the fovea displays the foveal depression. C, Retinal thickness map from optical coherence tomography of the same eye, generated from 6 radial scans through the fovea, displays the area of reduced retinal thickness with lesion boundaries not as well delineated as on the map obtained using the retinal thickness analyzer (Figure 2). f indicates the fovea.
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and
Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early
dhildhood mortality and growth failure data and their association with maternal
Thank you for submitting a comment on this article. It will be reviewed by JAMA Ophthalmology editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.